Evidence map›Paper›PMID 41303600›Full record

ArticleInternational journal of molecular sciences2025

Novel SNP Combination for Predictive Osteoporotic Diagnosis.

Julia V Sopova, Olga A Krasnova, Polina I Semenova, Julia D Kryukova, Giomar V Vasileva, Anna S Zhuk, Olga M Lesnyak, Vitaliy V Karelkin, Irina E Neganova

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julia V SopovaLaboratory of Molecular Medicine, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.ORCID 0000-0002-7825-273X
Olga A KrasnovaLaboratory of Molecular Medicine, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Polina I SemenovaLaboratory of Molecular Medicine, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Julia D KryukovaLaboratory of Molecular Medicine, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Giomar V VasilevaInstitute of Applied Computer Science, ITMO University, St. Petersburg 197101, Russia.
Anna S ZhukInstitute of Applied Computer Science, ITMO University, St. Petersburg 197101, Russia.ORCID 0000-0001-8683-9533
Olga M LesnyakDepartment of Family Medicine, North-Western State Medical University Named After I.I. Mechnikov, St. Petersburg 195298, Russia.ORCID 0000-0002-0143-0614
Vitaliy V KarelkinTraumatology and Orthopedics Department, Vreden National Medical Research Center of Traumatology and Orthopedics, St. Petersburg 195427, Russia.
Irina E NeganovaLaboratory of Molecular Medicine, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.

Funding

This work was supported by the Ministry of Science and Higher Education of the Russian Federation (the Federal Scientific-technical programme for genetic technologies development for 2019-2030 agreement N◦075-15-2025-529
6 · The paper itself

Abstract

Osteoporosis is a multifactorial disease, the pathogenesis of which is caused by a complex interaction of genetic, hormonal, and metabolic factors. The challenges of early diagnosis highlight the need to identify genetic predictors to prevent bone mineral density (BMD) loss. Given the critical role of G-protein-coupled receptors (GPCRs) in bone development and remodeling, we investigated osteoporosis-associated single-nucleotide polymorphisms (SNPs) within GPCR genes using next-generation sequencing of patient cohorts. Subsequent screening via Sanger sequencing identified three SNPs for further analysis: rs1991517 in the thyroid-stimulating hormone receptor gene (

Indexed as

OsteoporosisPolymorphism, Single NucleotideReceptors, Adrenergic, beta-2Receptors, FSHReceptors, ThyrotropinAgedBone DensityFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedADRB2 protein, humanReceptors, Adrenergic, beta-2Receptors, FSHReceptors, ThyrotropinADRB2FSHRGPCRosteodifferentiationosteoporosispolymorphismSNP combinationTSHR

Identifiers

PMID41303600
PMCPMC12652954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.