ReviewInternational journal of molecular sciences2025
Genetic Susceptibility to Sport-Related Muscle Injuries: Insights from the Literature and Novel Gene Candidates.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Article
- Skeletal Fiber Type in Muscle Pain and Dysfunction.Biomedicines · 2026Review
- Epigenetically Active Supplements and the Risk of Sports Injuries: Narrative Review from Molecular Mechanisms to Practical Implications.Nutrients · 2026Review
- Genes and Injuries in Sports: A Systematic Review and Meta-Analysis.Journal of human kinetics · 2026Review
- Construction and application of a model for predicting athletes' injury risk based on machine learning.BMC medical informatics and decision making · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical activity is widely recognized for its health benefits; however, it also increases the risk of musculoskeletal soft tissue injuries, with muscle-related cases constituting a considerable proportion. These injuries impair well-being, athletic performance, and career longevity while creating substantial social and economic burdens. Their multifactorial etiology involves internal and external risk factors, and evidence suggests a heritable component influencing tissue integrity, recovery, and overall susceptibility. While genetic contributions to ligament and tendon damage are relatively established, knowledge regarding muscle injuries remains limited. This review critically summarizes current evidence on polymorphisms associated with sport-related muscle injury susceptibility. A systematic search of PubMed, Scopus, and Web of Science identified studies examining genetic markers in physically active individuals with documented muscle injuries. To date, 37 single nucleotide polymorphisms in 32 genes have been significantly linked to injury risk, recurrence, severity, and recovery. These genes cluster into categories involving muscle structure, growth and regeneration, metabolism, inflammatory and stress responses, membrane stability, signaling, and vascular regulation. By integrating available findings and outlining knowledge gaps, this review highlights promising directions for advancing personalized prevention and rehabilitation strategies in sports medicine.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.