Evidence map›Paper›PMID 41303678›Full record

ArticleInternational journal of molecular sciences2025

Salivary Biomarkers in Crohn's Disease and Ulcerative Colitis: A Scoping Review and Evidence Map.

Karina Oliveira Santos, Ligia Yukie Sassaki, Maiara Brusco De Freitas, Julio Pinheiro Baima, Murilo Henrique Faria, Anna Luisa Bizotto, Júlia Pardini Benício, Ana Carolina Magalhães

Abstract readScoping Review
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karina Oliveira SantosDepartment of Biological Sciences, Bauru School of Dentistry (FOB), São Paulo University (USP), Bauru 17047-002, SP, Brazil.ORCID 0000-0001-6979-0045
Ligia Yukie SassakiDepartment of Internal Medicine, Medical School, São Paulo State University (UNESP), Campus Botucatu, Botucatu 18618-970, SP, Brazil.ORCID 0000-0002-7319-8906
Maiara Brusco De FreitasCenter for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University (AAU), 2450 Copenhagen, Denmark.ORCID 0000-0003-1737-8918
Julio Pinheiro BaimaDepartment of Internal Medicine, Medical School, São Paulo State University (UNESP), Campus Botucatu, Botucatu 18618-970, SP, Brazil.ORCID 0000-0002-4035-3113
Murilo Henrique FariaHuman Movement Research Laboratory (MOVI-LAB), Department of Physical Education, Faculty of Sciences, São Paulo State University (UNESP), Bauru 17033-360, SP, Brazil.ORCID 0000-0002-2375-9330
Anna Luisa BizottoDepartment of Biological Sciences, Bauru School of Dentistry (FOB), São Paulo University (USP), Bauru 17047-002, SP, Brazil.ORCID 0009-0006-1526-2048
Júlia Pardini BenícioDepartment of Biological Sciences, Bauru School of Dentistry (FOB), São Paulo University (USP), Bauru 17047-002, SP, Brazil.ORCID 0009-0000-0936-7157
Ana Carolina MagalhãesDepartment of Biological Sciences, Bauru School of Dentistry (FOB), São Paulo University (USP), Bauru 17047-002, SP, Brazil.ORCID 0000-0002-6413-5348

Funding

Karina Oliveira Santos has received a schorlaship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) 03/2025
6 · The paper itself

Abstract

Salivary biomarkers have been explored as potential non-invasive tools for the diagnosis and monitoring of inflammatory bowel diseases (IBD), including Crohn's Disease (CD) and Ulcerative Colitis (UC). This study presents a scoping review and evidence mapping on the use of saliva as a matrix in which biomarkers can be identified for these conditions. A systematic search of multiple databases and studies was conducted until 28 January 2025, resulting in the selection of 12 relevant articles. The quantified evidence synthesis identified eight molecular and microbial categories. Of these, four classes, including cytokines, microRNAs, calprotectin, and the microbiome, have demonstrated the most consistent potential. Alterations in these biomarkers, such as an increase in the

Indexed as

BiomarkersColitis, UlcerativeCrohn DiseaseSalivaCytokinesGastrointestinal MicrobiomeHumansMicroRNAsBiomarkersCytokinesMicroRNAsbiomarkersCrohn’s diseaseoral healthsalivaulcerative colitis

Identifiers

PMID41303678
PMCPMC12653261

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.