ArticleToxics2025
Impact of UV Aging on the Toxicity and Bioavailability of Inductively Coupled Plasma Mass Spectrometry (ICP-MS)-Traceable Core-Shell Polystyrene Nanoplastics in an In Vitro Triculture Small Intestinal Epithelium Model.
Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lifecycle Implications of Poly(vinyl chloride) (PVC) Micro(nano)plastics (MNPs): Interactions with Coexposed Environmental Pollutants (EPs) and Impact on Their Toxicity and Bioavailability.Environmental science & technology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
A major bottleneck in evaluating the environmental health implications of micro-nanoplastics (MNPs) is the inadequacy of analytical techniques for their precise quantification within complex environmental and biological matrices. Additionally, there is a conspicuous paucity of studies addressing environmentally relevant, photo-aged MNPs. In this study, the effects of UV aging on toxicity and bioavailability were investigated utilizing inductively coupled plasma mass spectrometry (ICP-MS)-traceable 25 nm gold-core polystyrene shell nanoplastics (AuPS25 NPs) and a triculture small intestinal epithelium (SIE) model coupled with simulated digestions to mimic physiological bio-transformations post-ingestion. Employing dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS), the physicochemical and morphological alterations of AuPS25 NPs as a function of UV exposure time were investigated, revealing significant photo-oxidation within 14 days. Toxicological evaluations demonstrated that, contrasting with un-aged AuPS25 NPs, the digesta from UV-aged AuPS25 NPs at oral concentrations of 4 and 40 µg/mL weakened barrier integrity by ~15% and ~18% and heightened cytotoxicity by ~4.3% and ~5.4%, respectively. Although the NP translocation rates were similar for both aged and un-aged PS NPs, the uptake by SIE of aged AuPS25 NPs was significantly higher, reaching 72.2% at 4 µg/mL and 59.2% at 40 µg/mL. In contrast, less than 0.5% of the un-aged PS NPs at both 4 µg/mL and 40 µg/mL were taken up by SIE. These findings highlight the imperative to integrate environmentally aged MNPs into toxicological assessments, as they facilitate "real-world" MNPs. Finally, the use of ICP-MS-traceable core-shell MNPs enables the identification and quantification of PS MNPs in cell lysates and biological media via ICP-MS, showcasing the use of such a tracer MNP approach in cellular uptake and in vivo biokinetic studies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.