Evidence map›Paper›PMID 41304714›Full record

ArticlePharmaceutics2025

Simian Immunodeficiency Virus-Derived Extracellular Vesicles Induce a Chronic Inflammatory Phenotype in Healthy Astrocytes Unresolved by Anti-Retroviral Therapy.

Alison R Van Zandt, Miranda D Horn, Ryan P McNamara, Tiffany A Peterson, Nicholas J Maness, Blake Schoest, Elise M Frost, Yijun Zhou, Matilda J Moström, Dirk P Dittmer and 1 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alison R Van ZandtTulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.ORCID 0000-0002-2773-101X
Miranda D HornTulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.
Ryan P McNamaraDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-8866-3532
Tiffany A PetersonTulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.
Nicholas J ManessTulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.ORCID 0000-0002-9332-7891
Blake SchoestTulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.
Elise M FrostTulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.
Yijun ZhouDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-0585-2689
Matilda J MoströmTulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.ORCID 0000-0001-7261-6638
Dirk P DittmerDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-4968-5656
Andrew G MacLeanTulane National Primate Research Center, Tulane University, Covington, LA 70433, USA.ORCID 0000-0002-0356-0674

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, NANCY JOAN RAAB-TRAUB · 1985 to 2026
$43.8M
Viral Testing CoreU42OD024282 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KASI E RUSSELL-LODRIGUE · 2017 to 2026
$25.7M
Viral Testing Core - Maintenance of an SPF Macaque Breeding Colony for AIDS ResearchU42OD010568 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KASI E RUSSELL-LODRIGUE · 2013 to 2026
$21.7M
Eradication of latent SIV from the CNSR01NS104016 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI LING, BINHUA "JULIE", MACLEAN, ANDREW G · 2017 to 2021
$3.7M
Exploratory Research on HIV Contribution to Heart and Lung ComorbiditiesR01HL152804 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI MACLEAN, ANDREW G · 2020 to 2023
$2.4M
High Throughput Multicolor Flow Cytometer Cell AnalyzerS10OD026800 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KAUR, AMITINDER · 2019 to 2019
$594k
Exosome Origin in HIV PathogenesisR21MH113517 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI MACLEAN, ANDREW G · 2017 to 2018
$470k
Reducing the CNS reservoir through myeloid cell depletionR21MH125716 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI MACLEAN, ANDREW G · 2021 to 2022
$468k
NCI NIH HHS P01 CA019014NHLBI NIH HHS R01 HL152804NIH HHS 1P01CA019014-03NIH HHS 1P51OD011104-54NIH HHS 1R01HL152804-04NIH HHS 1R01NS104016-03NIH HHS 1R21MH113517-01NIH HHS 1R21MH125716-01NIH HHS 1S10OD026800-01NIH HHS 1U42OD010568-02NIH HHS 1U42OD024282-02NIH HHS P51 OD011104NIH HHS S10 OD026800NIH HHS U42 OD010568NIH HHS U42 OD024282NIMH NIH HHS R21 MH113517NIMH NIH HHS R21 MH125716NINDS NIH HHS R01 NS104016
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

astrocyteexosomeextracellular vesicleglianeuroinflammation

Identifiers

PMID41304714
PMCPMC12655024

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.