Evidence mapPaperPMID 41304947Full record

ReviewPharmaceuticals (Basel, Switzerland)2025

Cardiovascular Therapeutics at the Crossroads: Pharmacological, Genetic, and Digital Frontiers.

Erica Vetrano, Alfredo Caturano, Davide Nilo, Giovanni Di Lorenzo, Giuseppina Tagliaferri, Alessia Piacevole, Mariarosaria Donnarumma, Ilaria Iadicicco, Sabrina Picco, Simona Maria Moretto and 7 more

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Erica VetranoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Alfredo CaturanoDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma University, 00166 Rome, Italy.ORCID 0000-0001-7761-7533
Davide NiloDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.ORCID 0009-0000-9617-4491
Giovanni Di LorenzoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Giuseppina TagliaferriDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Alessia PiacevoleDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Mariarosaria DonnarummaDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Ilaria IadiciccoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Sabrina PiccoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Simona Maria MorettoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Maria RoccoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Raffaele GalieroDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.ORCID 0000-0002-7766-3430
Vincenzo RussoSbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-9227-0360
Raffaele MarfellaDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.ORCID 0000-0003-3960-9270
Luca RinaldiDepartment of Medicine and Health Sciences "Vincenzo Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.
Leonilde BonfrateDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma University, 00166 Rome, Italy.
Ferdinando Carlo SassoDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.ORCID 0000-0002-9142-7848

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic innovation in cardiovascular medicine is rapidly overcoming the limitations of conventional strategies, providing more targeted, durable, and multidimensional solutions. Key advances include next-generation lipid-lowering agents such as PCSK9 inhibitors, inclisiran, and bempedoic acid, as well as metabolic drugs like SGLT2 inhibitors, GLP-1 receptor agonists, and dual GIP/GLP-1 agonists, which offer cardiovascular and renal benefits beyond glucose control. At the same time, gene therapies, RNA-based interventions, genome editing tools, and nanocarriers are paving the way for precision medicine tailored to individual patient profiles. In parallel, digital innovations, including artificial intelligence, remote monitoring, and telehealth platforms, are transforming care delivery by enhancing adherence, enabling earlier intervention, and refining risk stratification. Collectively, these developments signify a paradigm shift toward a more personalized, proactive, and systems-based model of cardiovascular care.

Indexed as

cardiovascular therapeuticsgene therapyGLP-1 receptor agonistsinclisirannanomedicinePCSK9 inhibitorsSGLT2 inhibitorstirzepatide

Identifiers

PMID41304947
PMCPMC12655567

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.