Evidence map›Paper›PMID 41304965›Full record

ReviewPharmaceuticals (Basel, Switzerland)2025

Point of Care Testing, Rapid Next Generation Sequencing and Artificial Intelligence in Pediatric and Neonatal Healthcare: A Narrative Review.

Alessandra Cianflone, Luigi Coppola, Pasquale Primo, Giovanna Maisto, Fiorenza Mastrodonato, Maria Antonia Di Palma, Rosanna Parasole, Daniela Omodei, Peppino Mirabelli

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessandra CianfloneUOS Laboratori di Ricerca e Biobanca, UOC Ricerca Clinica e Traslazionale, AORN Santobono-Pausilipon, Via Teresa Ravaschieri, n.8, 80129 Naples, Italy.
Luigi CoppolaUOS Laboratori di Ricerca e Biobanca, UOC Ricerca Clinica e Traslazionale, AORN Santobono-Pausilipon, Via Teresa Ravaschieri, n.8, 80129 Naples, Italy.
Pasquale PrimoUOS Laboratori di Ricerca e Biobanca, UOC Ricerca Clinica e Traslazionale, AORN Santobono-Pausilipon, Via Teresa Ravaschieri, n.8, 80129 Naples, Italy.ORCID 0000-0002-8700-8042
Giovanna MaistoDipartimento di Ematologia, Oncologia e Terapie Cellulari, AORN Santobono-Pausilipon, 80122 Naples, Italy.
Fiorenza MastrodonatoUOS Laboratori di Ricerca e Biobanca, UOC Ricerca Clinica e Traslazionale, AORN Santobono-Pausilipon, Via Teresa Ravaschieri, n.8, 80129 Naples, Italy.
Maria Antonia Di PalmaASL Napoli 3 Sud, 80059 Naples, Italy.
Rosanna ParasoleUOS Laboratori di Ricerca e Biobanca, UOC Ricerca Clinica e Traslazionale, AORN Santobono-Pausilipon, Via Teresa Ravaschieri, n.8, 80129 Naples, Italy.ORCID 0000-0003-3350-5286
Daniela OmodeiIstituto di Biostrutture e Bioimmagini-Consiglio Nazionale delle Ricerche (IBB-CNR), Via De Amicis 95, 80145 Naples, Italy.ORCID 0000-0001-8710-2971
Peppino MirabelliUOS Laboratori di Ricerca e Biobanca, UOC Ricerca Clinica e Traslazionale, AORN Santobono-Pausilipon, Via Teresa Ravaschieri, n.8, 80129 Naples, Italy.ORCID 0000-0002-2183-7577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laboratory tests play a crucial role in the diagnostic process for both adults and children. Indeed, they are essential for evaluating health status and formulating effective treatment strategies in the presence of disease. However, in the case of pediatrics, distinct physiological and developmental features of children should be taken into account when compared to adults. Consequently, it is necessary to consider some factors, such as reference intervals that vary significantly at different stages of development due to sexual development, cerebral maturation, and biological and environmental influences; furthermore, it must be considered that extremely small volumes of biological samples are often necessary to obtain accurate laboratory results. Finally, timely test results are critical, especially for pediatric conditions that are treatable when diagnosed early. This review article provides a comprehensive overview of advanced diagnostic technologies, including rapid next-generation sequencing and complex point-of-care testing, within the context of pediatric laboratory medicine. Special attention is given to diagnostic tools that support neonatal and pediatric intensive care units, with a focus on how innovative technologies, particularly those utilizing artificial intelligence algorithms, can accelerate diagnostic workflows.

Indexed as

artificial intelligencechildrendiagnosticsNICUpediatricsPICUPOCTrapid NGS

Identifiers

PMID41304965
PMCPMC12655080

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.