Genome-Based In Silico Analysis of the Structural and Functional Characteristics of the Type Three Secretion System (T3SS) and Core Effector Proteins in Enteropathogenic

Refiloe Malesa, Rian Pierneef, Thendo Mafuna, Kudakwashe Magwedere, Emmanuel Seakamela, Itumeleng Matle

Abstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Refiloe MalesaBacteriology Division, Agricultural Research Council-Onderstepoort Veterinary Research, Onderstepoort 0110, South Africa.ORCID 0000-0002-5205-695X

Rian PierneefDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria 0001, South Africa.ORCID 0000-0002-0619-0058

Thendo MafunaDepartment of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg 2001, South Africa.

Kudakwashe MagwedereCenter on Emerging Infectious Diseases, Boston University, 111 Cummington Mall, Suite 140, Boston, MA 02215, USA.

Emmanuel SeakamelaBacteriology Division, Agricultural Research Council-Onderstepoort Veterinary Research, Onderstepoort 0110, South Africa.ORCID 0000-0002-9212-1066

Itumeleng MatleDepartment of Agriculture and Animal Health, Science Campus, University of South Africa, Florida 1709, South Africa.ORCID 0000-0002-1495-357X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enteropathogenic

Indexed as

Enteropathogenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsGenome, BacterialType III Secretion SystemsVirulence FactorsAnimalsComputational BiologyComputer SimulationHumansEscherichia coli ProteinsType III Secretion SystemsVirulence FactorsEnteropathogenic E. colilocus of enterocyte effacementprotein domainsprotein–protein interactionprotein structureT3SStransmembrane domains

Identifiers

PMID41305337

DOI10.3390/pathogens14111099

PMCPMC12655248

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.