Evidence map›Paper›PMID 41305452›Full record

ArticleViruses2025

The Relationship Between Hemodynamic Responses During Head-Up Tilt Testing and Parameters of Infection in Post-COVID Syndrome, Chronic Fatigue Syndrome, and Late-Stage Lyme Disease.

Branislav Milovanovic, Nikola Markovic, Masa Petrovic, Smiljana Stojanovic, Vasko Zugic, Milijana Ostojic, Milovan Bojic

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Autonomic Dysfunction in Patients withPathogens (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Branislav MilovanovicInstitute for Cardiovascular Diseases "Dedinje", 11000 Belgrade, Serbia.
Nikola MarkovicInstitute for Cardiovascular Diseases "Dedinje", 11000 Belgrade, Serbia.ORCID 0009-0007-5090-6029
Masa PetrovicInstitute for Cardiovascular Diseases "Dedinje", 11000 Belgrade, Serbia.ORCID 0000-0003-1709-8449
Smiljana StojanovicInstitute for Cardiovascular Diseases "Dedinje", 11000 Belgrade, Serbia.
Vasko ZugicInstitute for Cardiovascular Diseases "Dedinje", 11000 Belgrade, Serbia.
Milijana OstojicInstitute for Cardiovascular Diseases "Dedinje", 11000 Belgrade, Serbia.
Milovan BojicInstitute for Cardiovascular Diseases "Dedinje", 11000 Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autonomic nervous system (ANS) dysfunction has emerged as a central feature of post-infectious syndromes, including post-COVID syndrome (PCS), chronic fatigue syndrome (CFS), and late-stage Lyme disease. This cross-sectional study included 1036 patients evaluated in the Neurocardiological Laboratory of the Institute for Cardiovascular Diseases "Dedinje," divided into four groups: PCS, CFS after COVID-19, CFS of insidious onset, and Lyme disease. All patients underwent head-up tilt testing (HUTT), and serological testing was performed in accredited institutions. The Lyme disease group demonstrated the highest prevalence of positive HUTT responses and a significantly greater frequency of orthostatic hypotension and syncope. Approximately 50-65% of patients in the PCS and Lyme groups were positive for IgM antibodies against at least one microorganism, with more than 10% showing positivity for three or more pathogens. Logistic regression analysis revealed that, beyond classical hemodynamic parameters, antibody status served as a significant predictor of HUTT outcomes, with specific associations identified for HSV-1, HHV-6,

Indexed as

COVID-19Fatigue Syndrome, ChronicHemodynamicsLyme DiseaseTilt-Table TestAdultAgedAntibodies, ViralCross-Sectional StudiesFemaleHumansImmunoglobulin MMaleMiddle AgedPost-Acute COVID-19 SyndromeSARS-CoV-2Antibodies, ViralImmunoglobulin Mchronic fatigue syndromehead-up tilt testlate-stage Lyme diseaseneurocardiologypost-COVID

Identifiers

PMID41305452
PMCPMC12656751

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.