Evidence map›Paper›PMID 41305527›Full record

ArticleViruses2025

Structural Analysis of Inhibitor Binding to the Feline Enteric Coronavirus (FECV) Main Protease.

Arooma Maryam, Stephanie A Moquin, Dustin Dovala, Jagroop Kaur, Nese Kurt Yilmaz, Ala M Shaqra, Celia A Schiffer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arooma MaryamDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-5479-2029
Stephanie A MoquinBiomedical Research, Novartis, Emeryville, CA 94608, USA.ORCID 0000-0002-8696-4315
Dustin DovalaBiomedical Research, Novartis, Emeryville, CA 94608, USA.
Jagroop KaurDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-4771-804X
Nese Kurt YilmazDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-5036-676X
Ala M ShaqraDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-6994-2416
Celia A SchifferDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0003-2270-6613

Funding

Defining and Avoiding Molecular Mechanisms of Drug ResistanceR35GM151996 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Celia A. Schiffer · 2024 to 2026
$1.5M
NIGMS NIH HHS 5R35GM151996-02NIGMS NIH HHS R35 GM151996
6 · The paper itself

Abstract

Coronaviruses include various strains that reside in natural animal reservoirs, with zoonotic transmission posing risks to both domesticated animals and human health. Recent efforts to address coronavirus infections have focused on developing inhibitors targeting the main protease (M

Indexed as

Antiviral AgentsCoronavirus, FelinePeptide HydrolasesProtease InhibitorsAnimalsBinding SitesCatalytic DomainCatsCrystallography, X-RayLactamsLeucineModels, MolecularProtein BindingSulfonic AcidsAntiviral AgentsGC376LactamsLeucinePeptide HydrolasesProtease InhibitorsSulfonic Acidscoronavirusescrystal structuredrug designmain proteaseprotease inhibitor

Identifiers

PMID41305527
PMCPMC12656910

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.