Evidence mapPaperPMID 41305569Full record

ReviewNutrients2025

Exploring the Role of Plant-Based Nutrition in Polycystic Kidney Disease.

Ahmad Sarmad, Niloufar Ebrahimi, Fouad T Chebib, Pranav S Garimella, Diana Bruen, Amir Abdipour, Sayna Norouzi

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmad SarmadDivision of Nephrology, Rush University Medical Center, Chicago, IL 60612, USA.
Niloufar EbrahimiDepartment of Medicine, Division of Nephrology, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.ORCID 0000-0003-2585-7820
Fouad T ChebibDivision of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3949-5720
Pranav S GarimellaDivision of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.
Diana BruenRenal Dietitian/Specialist in PKD, The PKD Dietitian, Henrico, VA, USA.
Amir AbdipourDepartment of Medicine, Division of Nephrology, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.ORCID 0000-0001-5204-1152
Sayna NorouziDepartment of Medicine, Division of Nephrology, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.

Funding

Kidney Tubular Damage and Dysfunction in Autosomal Dominant Polycystic Kidney DiseaseR01DK139291 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$690k
NIDDK NIH HHS R01 DK139291
6 · The paper itself

Abstract

Polycystic kidney disease (PKD) is a genetic disorder characterized by progressive kidney cyst formation and eventual kidney failure. Emerging evidence suggests that plant-based diets may confer therapeutic benefits in patients with PKD by modulating mTOR and AMPK signaling, reducing oxidative stress and inflammation, while improving metabolic and cardiovascular profiles. These diets, which are low in animal protein and rich in antioxidants, may help lower uric acid levels and support blood pressure control, thereby potentially reducing fibrosis. However, careful planning is required to avoid nutritional deficiencies. Well-designed clinical trials are warranted to validate their role in ADPKD management.

Indexed as

Diet, VegetarianPolycystic Kidney DiseasesAnimalsAntioxidantsDiet, Plant-BasedHumansKidneyOxidative StressSignal TransductionTOR Serine-Threonine KinasesUric AcidAntioxidantsTOR Serine-Threonine KinasesUric AcidADPKDautosomal dominant polycystic kidney diseasePKDplant-based dietpolycystic kidney disease

Identifiers

PMID41305569
PMCPMC12654993

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.