Observational studyMedicine2025
Association of insulin resistance-related indexes with atherosclerotic cardiovascular disease: A crosss-sectional study.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Associations of four insulin resistance indicators with subsequent pregnancy outcomes in women with recurrent pregnancy loss.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance (IR) is linked to atherosclerotic cardiovascular disease(ASCVD). This study analyzed data from the National Health and Nutrition Examination Survey to reveal the association of IR-related indexes with ASCVD in adults, aiming to improve risk assessment and early intervention. The study included adults from the National Health and Nutrition Examination Survey between 2007 and 2016. We used multivariable logistic regression to assess the link between IR-related indexes and ASCVD. Nonlinear associations were identified using restricted cubic splines and threshold effect analyses. Subgroup analysis confirmed result stability, while receiver operating characteristic curves compared the predictive performance of the indexes. Among 11,687 participants, 9.40% had ASCVD. A linear association between the metabolic score for IR (METS-IR) and ASCVD. The triglyceride-glucose index (TyG), homeostasis model assessment of IR (HOMA-IR), and triglyceride glucose-waist height ratio (TyG-WHtR) had nonlinear correlations with ASCVD prevalence. When TyG > 9.03, it was positively correlated with ASCVD (OR: 1.31, 95% CI: 1.07-1.60). An increase in HOMA-IR < 6.79 correlated with ASCVD risk (OR: 1.08, 95% CI: 1.04-1.12), but when HOMA-IR > 6.79, the increasing trend slowed down. When TyG-WHtR > 5.82, ASCVD risk was increased markedly with increasing values (OR: 1.32, 95% CI: 1.15-1.52), subgroup analysis showed a significant interaction between diabetes status and physical activity. Additionally, TyG-WHtR demonstrated superior predictive capacity for ASCVD (AUC = 0.644) compared to other indexes. Elevated IR levels are independently associated with increased ASCVD risk in American adults, with TyG-WHtR being the strongest predictor.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.