Evidence map›Paper›PMID 41306574›Full record

ArticleBio-protocol2025

A Computational Workflow for Membrane Protein-Ligand Interaction Studies: Focus on α5-Containing GABA (A) Receptors.

Syarifah Maisarah Sayed Mohamad, Khairul Bariyyah Abd Halim, Azzmer Azzar Abdul Hamid, Ahmad Tarmizi Che Has

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-protocol, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Syarifah Maisarah Sayed MohamadDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia.
Khairul Bariyyah Abd HalimResearch Unit for Bioinformatics and Computational Biology (RUBIC), Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Azzmer Azzar Abdul HamidDepartment of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Ahmad Tarmizi Che HasDepartment of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In neuropharmacology and drug development, in silico methods have become increasingly vital, particularly for studying receptor-ligand interactions at the molecular level. Membrane proteins such as GABA (A) receptors play a central role in neuronal signaling and are key targets for therapeutic intervention. While experimental techniques like electrophysiology and radioligand binding provide valuable functional data, they often fall short in resolving the structural complexity of membrane proteins and can be time-consuming, costly, and inaccessible in many research settings. This study presents a comprehensive computational workflow for investigating membrane protein-ligand interactions, demonstrated using the GABA (A) receptor α5β2γ2 subtype and mitragynine, an alkaloid from

Indexed as

GABA (A) receptorMembrane protein modelingMolecular dockingMolecular dynamics simulationReceptor–ligand interaction

Identifiers

PMID41306574
PMCPMC12645288

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.