ArticleCureus2025
Preoperative Indicators of Graft Rejection in Patients With Heart Transplantation: A Single-Center Retrospective Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHeart failure (HF) represents a syndrome characterized by the heart's inability to fulfill its pump role due to a decrease in its mechanical function or abnormal filling pressures. This disease is one of the focus areas in modern research, with medication and mechanical assistance devices being constantly developed. The final treatment option, when all the medical and device therapies have been exhausted, is represented by the heart transplant. Patients undergoing heart transplant face biological and psychological challenges, which must be addressed by attending physicians to increase the survival and quality of life of these individuals. The aim of this study was to describe the population who received a heart transplant in our center over 12 years and to assess potential connections between the etiology of cardiomyopathy associated with end-stage HF of the organ recipient and clinical and paraclinical outcomes.
methodsWe collected data for the patients who underwent a cardiac transplant in our center between 2011 and 2023, forming an initial cohort of 51 patients. Seven patients were excluded for incomplete data sheets, resulting in a final cohort of 44 patients. Means and medians were compared between the ischemic and nonischemic groups, and associations were investigated for each group with hospitalization parameters and clinical and histopathological outcomes.
resultsWe found that the patients in the ischemic group had a higher mean age, weight, body mass index, and body surface area, while the nonischemic group has been associated with the development of the Quilty effect and graft rejection. Furthermore, the expression of the human leukocyte antigen-A variant was associated with graft rejection and Quilty effect.
conclusionIdentifying factors that may predict or contribute to postoperative success is of utmost importance. Further studies are required to validate these results.
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