ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Interaction Between Photoperiod and Sex on Hepatic Lipid Homeostasis in Rats Fed an Obesogenic Diet.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Interaction Between Photoperiod and Sex on Hepatic Lipid Homeostasis in Rats Fed an Obesogenic Diet.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Seasonal changes in day length as well as sex are critical factors influencing metabolic processes. However, their combined impact on liver lipid metabolism under obesogenic conditions remains unclear. This study aims to investigate the interaction between sex and photoperiod on liver lipid homeostasis in obese Fischer 344 (F344) rats, with a special emphasis on the underlying molecular mechanisms. To this aim, male and female rats were fed with a cafeteria diet (CAF) for 11 weeks and exposed to either long (L18, 18 h of light/day) or short (L6, 6 h of light/day) photoperiods for the last 8 weeks. Liver histological analysis, hepatic damage markers, plasmatic and hepatic lipid profiles as well as hepatic gene expression related to lipid metabolism were performed. Results indicate that males exposed to the L18 photoperiod developed hepatic macro-steatosis and exacerbated hepatic lipid accumulation, leading to increased liver weight and total hepatic lipids compared to their L6 photoperiod counterparts. At the molecular level, males under the L18 photoperiod, showed downregulation of the lipid transporter Fabp4 and upregulation of β-oxidation related genes. On the other hand, female rats exhibited a healthier lipid profile compared to males when exposed to both L6 and L18 photoperiods, and a lower degree of steatosis. Gene analysis revealed that the lipid transporter Mtp expression was significantly higher in females under the L18 photoperiod. In conclusion, photoperiod and sex influence hepatic lipid metabolism in rats fed an obesogenic diet, highlighting the importance of considering these factors in understanding and addressing metabolic disorders and reinforcing the concept of precision medicine.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.