ReviewCancer reports (Hoboken, N.J.)2025
The Evaluation of Diagnostic, Prognostic, and Predictive Role of Hematologic Inflammatory Indices NLR, PLR, and LMR in Common Solid Tumors.
Review in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy and association with lymph node metastasis of the systemic immune-inflammation index in thyroid cancer: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- CONUT score and Naples prognostic score (NPS) for dual prediction of survival and radiation toxicity in locally advanced non-small cell lung cancer with chemoradiotherapy.Journal of thoracic disease · 2026Article
- Preoperative Immunonutritional Indices in Colorectal Cancer: The Contribution of Albumin, Time-Dependence of Effect, and Threshold Transportability in a Saudi Cohort.Current oncology (Toronto, Ont.) · 2026Article
- Exploratory Development and Interpretation of an Internally Validated XGBoost-Cox Model Based on Preoperative Inflammation-Nutrition Indices for Overall Survival in Primary Pathological Stage I Rectal Cancer.Current oncology (Toronto, Ont.) · 2026Article
- Perioperative NLR/PLR dynamic phenotypes and prediction of postoperative recurrence in locally advanced gastric cancer: a retrospective cohort study.BMC cancer · 2026Article
- A Prospective Case-Control Study of Helicobacter pylori and Systemic Inflammation in Colorectal Cancer Pathogenesis.Cureus · 2026Article
- Examining the association between diet quality scores, inflammation and treatment outcomes in pediatric acute lymphoblastic leukemia: an exploratory observational study.BMC nutrition · 2026Article
- Predictors of response and survival in cemiplimab-treated cutaneous squamous cell carcinoma: multicenter real-world evidence from Germany.Journal of cancer research and clinical oncology · 2026Article
- Interpretable Machine Learning Models Based on Blood Cell-Derived Inflammatory Indices for Identifying Colorectal Neoplasia: A Retrospective Study.Journal of inflammation research · 2026Article
- Peripheral blood biomarkers in PD-1/PD-L1 immunotherapy: distinguishing predictive from prognostic biomarkers.Frontiers in immunology · 2026Review
- Neutrophil extracellular traps and acute kidney injury: a narrative review.Frontiers in immunology · 2026Review
- The Evaluation of Diagnostic, Prognostic, and Predictive Role of Hematologic Inflammatory Indices NLR, PLR, and LMR in Common Solid Tumors.Cancer reports (Hoboken, N.J.) · 2025Review
- Prognostic value of the C-reactive protein-albumin-lymphocyte index versus traditional inflammatory markers after radical resection of colorectal cancer: a retrospective cohort study.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSolid tumors are one of the leading causes of cancer-related deaths. Measurable combined inflammatory markers in the blood, which indicate the inflammatory response, play a crucial role in managing patients with malignancies. These markers have been validated as less invasive, practical, and cost-effective tools in the clinical decision-making process. The aim of this study is to evaluate the predictive value of inflammatory markers based on complete blood count (CBC), including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in major solid tumors, including breast, lung, colorectal, and prostate cancers, due to their high prevalence and strong evidence base. RECENT
findingsIn this study, studies from 2015 to June 2025 were searched in Google Scholar, PubMed, and Scopus using keywords such as neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, prognosis value, predictive value, diagnosis value, lung cancer, colon cancer, prostate cancer, and breast cancer. Findings indicate that elevated NLR and PLR, alongside reduced LMR, are commonly associated with advanced disease, poorer survival, and diminished response to treatment, though the strength of evidence varies by cancer type. Limitations across studies include retrospective design, inconsistent cut-off values, and confounding factors such as comorbidities and treatment regimens.
conclusionCurrent evidence suggests that NLR, PLR, and LMR have significant potential as accessible biomarkers for risk stratification and treatment monitoring in common solid tumors. However, lack of standardization in methodology and cut-off definitions limits their widespread clinical implementation. High-quality prospective studies are needed to establish unified thresholds and clarify their role alongside established biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.