ArticleJournal of diabetes investigation2026
Comparison of the correlation between triglyceride-glucose index and homeostasis model assessment of insulin resistance with subclinical left ventricular dysfunction.
Article in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Insulin Resistance Indices and Subclinical Left Ventricular Systolic Dysfunction in Adults: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2026Pooled it
- Triglyceride-Glucose-Waist-to-Height Ratio Index and Left Ventricular Diastolic Function in Military Athletes.JACC. Advances · 2026Article
- TyG index and mild cognitive impairment and dementia: a review of current evidence.Frontiers in aging neuroscience · 2026Review
- Triglyceride-glucose index and subclinical left ventricular dysfunction across cardiovascular-kidney-metabolic syndrome stages: a 7-year retrospective cohort study.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
AIMS/
introductionWe aimed to explore the association of the triglyceride-glucose (TyG) index and homeostasis model assessment of insulin resistance (HOMA-IR) with subclinical left ventricular function in the general population. MATERIALS AND
methodsA total of 2,850 participants with left ventricular ejection fraction ≥50% were recruited from 2017 to 2019 in Danyang. Speckle-tracking echocardiography (Philips CX50) was used to measure global longitudinal strain (GLS). Subclinical left ventricular systolic dysfunction (LVSD) was defined as GLS < 18%.
resultsIn univariate analyses, higher TyG index and HOMA--IR were significantly associated with reduced GLS, lower E/A ratio and e', and higher E/e' ratio (P < 0.001). After adjustment for confounders, HOMA-IR remained significantly associated with lower GLS (P = 0.002), whereas the TyG index showed stronger correlations with E/e' ratio (P < 0.01). The inclusion of log-transformed HOMA-IR significantly improved model fit in analyses incorporating GLS and TyG index (P = 0.004) but not in those with E/e' ratio and TyG index (P = 0.65). Conversely, the TyG index enhanced model performance for the E/e'-HOMA-IR association (P < 0.001) but not for GLS-HOMA-IR relationships (P = 1). In addition, participants in the highest versus lowest HOMA-IR quartile demonstrated significantly increased odds ratio of subclinical LVSD (OR = 2.22, 95% CI: 1.26-3.92; P = 0.006), while the TyG index showed no significant association with its prevalence (P = 0.98).
conclusionsIn a community-based population, elevated HOMA-IR demonstrated a robust association with subclinical LVSD, whereas the TyG index exhibited a more pronounced correlation with early diastolic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.