ArticlePsychopharmacology2025
A classic traditional chinese medicine formula for depression: mechanistic insights from phytochemical constituents and multitarget pathways.
Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
rationaleDepression is a common mood disorder that seriously affects the quality of life and working ability of patients. Zhi-Zi-Hou-Po Decoction (ZZHPD), a classical formula from the Traditional Chinese Medicine (TCM), is widely used to treat depression. Although ZZHPD exhibits potent antidepressant effects, its specific mechanism of action and active ingredients remain unknown.
objectivesThis article focused on identifying and analysing the major phytochemical in ZZHPD that exhibit antidepressant effects. It also provided theoretical data for the standardized clinical application of ZZHPD.
methodsA systematic review of the materia medica, chemical composition, and pharmacological effects from multi-source literature databases to elucidate the antidepressant mechanism of ZZHPD. And further validation was performed using a comprehensive bioinformatics analysis of network pharmacology and molecular docking.
resultsThe antidepressant effect of ZZHPD is achieved through multiple pathways and targets. The key phytochemical constituents of ZZHPD include 3 categories, iridoids, flavonoids, and lignans, which are specifically included geniposide, magnolol, honokiol, hesperidin, hesperetin, naringin, naringenin, nobiletin, and 3,5,6,7,8,3',4'-heptamethphoxyflavone (HMF). The main antidepressant mechanisms include enhancing monoaminergic system function, inhibiting neuroinflammation, restoring HPA axis negative feedback, enabling neurogenesis and neuroplasticity, neuroprotective effects, inhibition of neuronal apoptosis and pyroptosis, antioxidative stress, and regulation of noncoding RNA.
conclusionsIn summary, ZZHPD demonstrates antidepressant effects through multi-component, multi-target, and multi-pathway mechanisms. It shows promise for treating depression at the molecular, cellular, and systemic levels, with significant clinical application value.
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