Evidence map›Paper›PMID 41307682›Full record

ArticleAnalytical and bioanalytical chemistry2026

Ultrasound-assisted extraction of bioactive birch (Betula sp.) bark triterpenoids using hydrophobic natural deep eutectic solvents.

I Luque-Jurado, S Rivas, R Lebrón-Aguilar, J E Quintanilla-López, M L Sanz, A C Soria

Abstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

I Luque-JuradoInstituto de Química Orgánica General (CSIC), Juan de la Cierva, 3 28006, Madrid, Spain.ORCID http://orcid.org/0009-0009-3987-1560
S RivasInstituto de Química Orgánica General (CSIC), Juan de la Cierva, 3 28006, Madrid, Spain.ORCID http://orcid.org/0000-0002-6348-2452
R Lebrón-AguilarInstituto de Química Física Blas Cabrera (CSIC), Serrano, 119 28006, Madrid, Spain.ORCID http://orcid.org/0000-0001-6103-6814
J E Quintanilla-LópezInstituto de Química Física Blas Cabrera (CSIC), Serrano, 119 28006, Madrid, Spain.ORCID http://orcid.org/0000-0003-1863-7408
M L SanzInstituto de Química Orgánica General (CSIC), Juan de la Cierva, 3 28006, Madrid, Spain.ORCID http://orcid.org/0000-0002-8156-4734
A C SoriaInstituto de Química Orgánica General (CSIC), Juan de la Cierva, 3 28006, Madrid, Spain. acsoria@iqog.csic.es.ORCID http://orcid.org/0000-0001-8045-3883

Funding

Comunidad de Madrid IND2020/BIO-17409CSIC project 202180I003MICIU/AEI/10.13039/501100011033 and by ERDF/EU PID2023-149799OB-C21MICIU/AEI/10.13039/501100011033 and by ERDF/EU PID2023-149799OB-C22
6 · The paper itself

Abstract

The simultaneous extraction of high-value bioactive triterpenoids, betulin (Bet) and betulinic acid (BAc), from birch (Betula sp.) bark has been optimized and analytically characterized to provide an improved approach in terms of efficacy and sustainability. First, in silico screening of numerous conventional organic solvents, biosolvents and hydrophobic natural deep eutectic solvents (h-NADESs) via the COSMO-RS theory revealed thymol:1-octanol (molar ratio of 4:1) as the optimal extractant (Bet + BAc solvent capacity,

Indexed as

BetulaDeep Eutectic SolventsPlant BarkPlant ExtractsTriterpenesBetulinic AcidHydrophobic and Hydrophilic InteractionsPentacyclic TriterpenesUltrasonicsUltrasonic WavesbetulinBetulinic AcidDeep Eutectic SolventsPentacyclic TriterpenesPlant ExtractsTriterpenesAGREEprepBioactive triterpenoidsBirch (Betula sp.) barkCOSMO-RSHydrophobic natural deep eutectic solvents (h-NADESs)Ultrasound-assisted extraction (UAE)

Identifiers

PMID41307682
PMCPMC12960316

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.