Evidence map›Paper›PMID 41307749›Full record

ReviewCurrent pain and headache reports2025

Clinical Efficacy of Magnesium in Perioperative Pain Management: A Narrative Review.

Shahab Ahmadzadeh, Joseph G Wentling, Bennett M Ford, Jade Alexandra Tom Yew, Sonnah A Barrie, Faline Y Bernhardt, Sahar Shekoohi, Alaa Abd-Elsayed, Alan D Kaye

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shahab AhmadzadehDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.
Joseph G WentlingSchool of Medicine, Louisiana State University Health Sciences Center at New Orleans, New Orleans, LA, 70112, USA.
Bennett M FordSchool of Medicine, Louisiana State University Health Sciences Center at New Orleans, New Orleans, LA, 70112, USA.
Jade Alexandra Tom YewDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.
Sonnah A BarrieDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.
Faline Y BernhardtDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.
Sahar ShekoohiDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA. sahar.shekoohi@lsuhs.edu.
Alaa Abd-ElsayedDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Alan D KayeDepartment of Anesthesiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewPostoperative pain is a prevalent clinical challenge that often leads to high opioid consumption, delayed hospital discharge, and associated side effects. Inadequate pain control can delay recovery and contribute to the risk of chronic postsurgical pain and opioid dependence. Magnesium, an essential cation with diverse physiological roles, has gained attention as a non-opioid adjunct for perioperative analgesia related to multimodal mechanisms of action and a favorable profile. RECENT

findingsPharmacologically, magnesium acts as an N-methyl-D-aspartate (NMDA) receptor antagonist and calcium channel blocker in the central nervous system, dampening excitatory neurotransmission and reducing central sensitization to pain. It also exhibits anti-inflammatory and anti-nociceptive effects and is inexpensive and easy to administer intravenously. These properties make magnesium a cost-effective and simple addition to multimodal pain management protocols. When used as a preoperative or intraoperative adjunct, magnesium has demonstrated reduced postoperative pain intensity and decreased opioid requirements across various surgical populations. Trials and meta-analyses report that patients receiving perioperative magnesium experience lower pain scores and need fewer opioids in the first 24-48 hours after surgery, translating into an opioid-sparing effect and potentially less opioid-related nausea and sedation. Importantly, magnesium has a favorable safety profile at recommended doses and generally is well-tolerated with minimal side effects apart from infrequent hypotension or mild sedation. No significant respiratory depression occurs in patients with normal renal function. The present investigation highlights magnesium-mediated analgesic mechanisms, summarizes clinical evidence for efficacy as a preoperative pain adjunct, and describes implications for improving postoperative pain outcomes and reducing opioid reliance in perioperative care.

Indexed as

AnalgesicsMagnesiumPain ManagementPerioperative CarePostoperative PainHumansAnalgesicsMagnesiumAnalgesic adjunctMagnesium sulfateMultimodal analgesiaNMDA receptor antagonistOpioid-sparingPerioperative pain managementPostoperative pain

Identifiers

PMID41307749

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.