Evidence map›Paper›PMID 41307805›Full record

ArticleCell biochemistry and biophysics2026

Flavonoid-Rich Extracts from Mentha Piperita and their Novel Role in ALT Modulation in a Cardiovascular Disease Rat Model.

Nuha Ali Hadi Al-Samarrie, Huda Ghazi Naser, Suror A Mahdi, Rasha Saad Jwad, Mohammed Basil Anwer, Zamzam Alhuwaymil, Sohad A Alshareef, Mohammed S S Alyami, Mohammed H Al-Mashhadani, Great Iruoghene Edo

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Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Nuha Ali Hadi Al-SamarrieDepartment of Chemistry, College of Education, University of Samarra, Samarra,, Iraq.
Huda Ghazi NaserDepartment of Applied Pathological Analysis, College of Sciences, Al- Nahrain University, P. O. Box: 64021, Baghdad, Iraq.
Suror A MahdiDepartment of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq.
Rasha Saad JwadDepartment of Medical Physics, College of Sciences, Al-Nahrain University, P. O. Box: 64021, Baghdad, Iraq.
Mohammed Basil AnwerDepartment of Medical Physics, College of Sciences, Al-Nahrain University, P. O. Box: 64021, Baghdad, Iraq.
Zamzam AlhuwaymilDepartment of Chemistry, College of Science and Humanites at Al- Quway'iyah, Shaqra University, Shaqra, Saudi Arabia.
Sohad A AlshareefUniversity College of Duba, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Mohammed S S AlyamiDepartment of Science, King Abdulaziz Military College, Riyadh, 14514, Saudi Arabia.
Mohammed H Al-MashhadaniDepartment of Chemistry, College of Sciences, Al-Nahrain University, P. O. Box: 64021, Baghdad, Iraq.
Great Iruoghene EdoDepartment of Chemistry, Faculty of Science, Delta State University of Science and Technology, Ozoro, Nigeria. greatiruo@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are a serious global health burden. Flavonoids are polyphenolic compounds with strong antioxidant properties and significant capabilities to reduce oxidative stress, a key factor in CVD development. This study investigates the effect of ethanolic extract of Mentha × piperita, a rich source of flavonoids, on heart disease in rats. Heart disease was experimentally induced by administering 1% hydrogen peroxide (H₂O₂) for 21 days. Twenty-five male rats were divided into five groups: control, H₂O₂-treated, and three groups treated with different concentrations of flavonoid extract (100, 150, and 200 mg/kg/day). Biochemical tests showed that the obtained flavonoid reduced serum ALT activity (p < 0.05) and enhanced lipid profiles by lowering total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL). On the other hand, the high-density lipoprotein (HDL) has significantly increased. The outcomes demonstrated that the antioxidant activity of flavonoids plays an important role in decreasing oxidative stress and protecting against H₂O₂-induced cardiovascular damage. The findings highlight the translational potential of Mentha-derived flavonoids as natural therapeutic agents for improving lipid metabolism and reducing cardiovascular risk in humans.

Indexed as

Cardiovascular DiseasesFlavonoidsMentha piperitaPlant ExtractsAnimalsAntioxidantsCholesterolDisease Models, AnimalHydrogen PeroxideLipoproteins, LDLMaleOxidative StressRatsRats, WistarTriglyceridesAntioxidantsCholesterolFlavonoidsHydrogen PeroxideLipoproteins, LDLPlant ExtractsTriglyceridesAntioxidantCardiovascular diseasesEthanolic extractNatural therapeuticsOxidative stress

Identifiers

PMID41307805

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.