ArticleJournal of global health2025
Impact of chronic kidney disease on the incidence of visual impairment and age-related eye diseases in a multi-ethnic Asian population.
Article in Journal of global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The kidney and eye share common metabolic and vascular risk factors, and chronic kidney disease (CKD) has been associated with the prevalence of visual impairment (VI). In this study, we examined the association of CKD with incident VI and major age-related eye diseases, including cataract, age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma, in a multi-ethnic Asian population. Methods: We analysed data from 6486 Chinese, Malay, and Indian adults aged 40-80 years who participated in the Singapore Epidemiology of Eye Diseases study at baseline (2004-11) and six-year follow-up visit (2011-17) and were free of VI and the respective eye diseases at baseline. We defined CKD (n = 564; 8.7%) as an estimated glomerular filtration rate (eGFR)<60 ml/min/1.73 m Results: CKD participants had a higher incidence of any VI (14.3% vs. 3.3%; P < 0.001), any AMD (8.0% vs. 5.4%; P < 0.001), and cataracts (65.1% vs. 40.8%; P < 0.001) than non-CKD participants. VI incidence increased with CKD severity in G1-G2 (3.3%), G3a (13.5%), and G3b-G5 (16.3%) (P < 0.001). In multivariable models, CKD was associated with incident VI (OR = 1.47; 95% CI = 1.03-2.10) and moderate/worse DR (OR = 2.62; 95% CI = 1.35-5.10). Conclusions: Our results suggest that the presence of CKD increases the risk and severity of VI and eye diseases in Asian adults. Our findings highlight the importance of regular eye exams for CKD patients to reduce the risk of VI.
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