Evidence map›Paper›PMID 41308065›Full record

ReviewHormone research in paediatrics2025

EndoCompass Project: Research Roadmap for Reproductive and Developmental Endocrinology.

Martine Cools, Csilla Krausz, Anders Juul, Djuro Macut, Marianne Skovsager Andersen, Anna-Maria Andersson, Cynthia L Andoniadou, S Faisal Ahmed, Julie Bakker, Anu Bashamboo and 42 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hormone research in paediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

Martine CoolsDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
Csilla KrauszDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy, csilla.krausz@unifi.it.
Anders JuulDepartment of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark.
Djuro MacutClinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Marianne Skovsager AndersenEndocrinology, Odense Universitetshospital, Odense, Denmark.
Anna-Maria AnderssonDepartment of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark.
Cynthia L AndoniadouCentre for Craniofacial and Regenerative Biology, King's College London, Faculty of Dentistry, Oral and Craniofacial Sciences, London, UK.
S Faisal AhmedDevelopmental Endocrinology Research Group, University of Glasgow, Glasgow, UK.
Julie BakkerDépartement des Sciences Biomédicales et Précliniques Biologie de la Différenciation Sexuelle du Cerveau GIGA Neurosciences-Neuroendocrinology, University of Liege, Liege, Belgium.
Anu BashambooHuman Developmental Genetics Unit, CNRS (UMR 373), Institut Pasteur, Université Paris Cité, Paris, France.
Hermann M BehreCenter for Reproductive Medicine and Andrology, University of Halle, Halle, Germany.
Marco BonomiDepartment of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Alexander Siegfried BuschDepartment of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark.
Chloë De RooDepartment for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.
Arianne DessensDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
Muhammad Fakhar-I-AdilGhent-Fertility and Stem Cell Team (G-FaST), Department for Reproductive Medicine, Department of Human Structure and Repair, Ghent University Hospital, Ghent, Belgium.
Flaminia FanelliDepartment of Medical and Surgical Sciences, University of Bologna Hospital of Bologna Sant'Orsola-Malpighi Polyclinic, Bologna, Italy.
Alessandra Daphne FisherCareggi University Hospital, Florence, Italy.
Christa FlückPediatric Endocrinology, Diabetology and Metabolism, University Childrens Hospital, Bern, Switzerland.
Alessandra GambineriDepartment of Medical and Surgical Sciences, University of Bologna Hospital of Bologna Sant'Orsola-Malpighi Polyclinic, Bologna, Italy.
Aleksander GiwercmanDeparment of Translational Medicine, Lund University, Lund, Sweden.
Claus H GravholtDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Sabine HannemaDepartment of Paediatrics, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Björn HeindryckxGhent-Fertility and Stem Cell Team (G-FaST), Department for Reproductive Medicine, Department of Human Structure and Repair, Ghent University Hospital, Ghent, Belgium.
Olaf HiortDivision of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University of Lübeck, Lubeck, Germany.
Nadine C HornigInstitute of Human Genetics, Christian-Albrechts-University of Kiel, Kiel, Germany.
Sasha HowardCentre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Lourdes IbáñezDepartment of Endocrinology, Hospital Sant Joan de Déu, Barcelona, Spain.
Martin Blomberg JensenDivision of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Niels JørgensenDepartment of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark.
Sarantis LivadasUnit of Endocrinology, Athens Medical Centre, Athens, Greece.
Angela Lucas-HeraldDevelopmental Endocrinology Research Group, University of Glasgow, Glasgow, UK.
George MastorakosFaculty of Medicine, Endocrine Unit, "Aretaieion" Hospital, National and Kapodistrian University of Athens, Athens University, Athens, Greece.
Maria Cristina MeriggiolaDepartment of Medical and Surgical Sciences, University of Bologna Hospital of Bologna Sant'Orsola-Malpighi Polyclinic, Bologna, Italy.
Ken OngMRC Epidemiology Unit, Childhood Obesity, Cambridge, UK.
Milica Opalic PalibrkClinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Duarte PignatelliFaculty of Medicine, University of Porto, Porto, Portugal.
Nelly PitteloudCHUV, EDM, Lausanne, Switzerland.
Ewa Rajpert-De MeytsDepartment of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark.
Rodolfo ReyCONICET-FEI-División Endocrinología, Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), Hospital de Niños R Gutiérrez, Buenos Aires, Argentina.
Ralitsa RobevaMedical University-Sofia, MF, Department of Endocrinology, USHATE "Acad. Iv. Penchev", Sofia, Bulgaria.
Carlotta PozzaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Stefan SchlattCeRA, University Münster, Münster, Germany.
Giorgia SpaggiariUnit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy.
Lloyd TackDepartment of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.
Manuel Tena-SemperePhysiology Section, Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Cordoba, Spain.
Herman TournayeBrussels IVF, The Centre for Reproductive Medicine of the Dutch-speaking Brussels Free University Hospital VUB, Brussels, Belgium.
Guy T'SjoenEndocrinology, University Hospital Gent, Gent, Belgium.
Norah Van MelloCenter of Expertise on Gender Dysphoria, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.
Walter VenaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Bulent O YildizDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Hacettepe University School of Medicine, Ankara, Turkey.
Francis de ZegherDepartment of Development and Regeneration, Woman and Child, University of Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At national funding level, endocrine societies report limited or little attention of national research funding towards endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Paediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.

methodsResearch priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation was conducted to identify key research priorities, followed by broader stakeholder engagement including society members and patient advocacy groups.

resultsResearch priorities encompass variations in sex development, hypothalamic-pituitary-gonadal regulation, and female and male reproductive disorders. Key areas include improving diagnostic capacity through (epi)genetic analysis, optimizing hormonal treatments, developing fertility preservation strategies. Special emphasis is placed on establishing pan-European registries, developing novel reproductive technologies, and exploring environmental impacts on reproductive health.

conclusionsThis component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into reproductive and developmental endocrinology pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of the highest potential impact in endocrine health.

Indexed as

Biomedical ResearchDatabases, FactualEndocrine System DiseasesEndocrinologyFemaleHumansMaleEndoCompassFundingHypothalamic-pituitary-gonadal·axisReproductionRoadmap

Identifiers

PMID41308065
PMCPMC12698133

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.