Evidence map›Paper›PMID 41308562›Full record

ArticleHearing research2026

Age-related hearing loss involves mitochondrial DNA instability and copy number depletion in the cochlea: Insights from in vivo and in vitro models.

Akil Turner, Bo Ding, Xiaoxia Zhu, Tam Nguyen, Parveen Bazard, Robert D Frisina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akil TurnerDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL, 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL, 33612, USA; Department of Chemical and Biochemical, Missouri University of Science and Technology, Rolla, MO, 65409, USA; Center for Biomedical Research, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Bo DingDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL, 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL, 33612, USA. Electronic address: ding1@usf.edu.
Xiaoxia ZhuDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL, 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL, 33612, USA.
Tam NguyenDepartment of Computer Science and Engineering, University of South Florida, Tampa, FL, 33620, USA.
Parveen BazardDepartment of Chemical and Biochemical, Missouri University of Science and Technology, Rolla, MO, 65409, USA; Center for Biomedical Research, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Robert D FrisinaDepartment of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL, 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL, 33612, USA. Electronic address: rfrisina@usf.edu.

Funding

Structure and Function Services CoreP01AG009524 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI FRISINA, ROBERT D · 1992 to 2021
$23.2M
Sex Effects for Hearing Loss Drug TherapiesR21DC021546 · NIDCD · UNIVERSITY OF SOUTH FLORIDA · PI BAZARD, PARVEEN, FRISINA, ROBERT D · 2023 to 2023
$413k
NIA NIH HHS P01 AG009524NIDCD NIH HHS R21 DC021546
6 · The paper itself

Abstract

Age-related hearing loss (ARHL) is a highly prevalent sensory neurodegenerative disorder that involves various molecular mechanisms. The present study investigated if age-related oxidative stress (OS) induces alterations in mitochondrial DNA (mtDNA) copy number and heteroplasmy, using complementary in vivo and in vitro models. Aged (30-month) CBA/CaJ mice have elevated auditory brainstem response (ABR) thresholds amplitudes vs. young (3-month) CBA/CaJ mice, a key physiological characteristic of ARHL The in vitro experiments employed the strial SV-K1 cochlear cell line treated with hydrogen peroxide (H

Indexed as

AgingCochleaDNA Copy Number VariationsDNA, MitochondrialHearingPresbycusisAge FactorsAnimalsAuditory ThresholdCell LineCytochromes bDisease Models, AnimalElectron Transport Complex IVEvoked Potentials, Auditory, Brain StemHeteroplasmyHydrogen PeroxideCytochromes bDNA, MitochondrialElectron Transport Complex IVHydrogen PeroxideAge-related hearing lossAgingCochleaGeneMitochondrionMutationOxidative stress

Identifiers

PMID41308562
PMCPMC13621387

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.