Evidence map›Paper›PMID 41308637›Full record

ArticleCell2026

Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity.

Emily Scott-Solomon, Shlomi Brielle, Alexander O Mann, Mark J Khoury, Jingyu Peng, Liana Tellez, Mackenzie Harrigan, Myrto Ziogas, H Amalia Pasolli, Monica Cassandras and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emily Scott-SolomonDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Shlomi BrielleDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Alexander O MannDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Department of Immunology, Harvard Medical School, Boston, MA 02215, USA.
Mark J KhouryDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Jingyu PengDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Liana TellezDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Mackenzie HarriganDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Myrto ZiogasDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
H Amalia PasolliElectron Microscopy Resource Center, The Rockefeller University, New York, NY 10065, USA.
Monica CassandrasDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Adam J GetzlerDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Rebecca FreemanDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Bing ZhangDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Yulia ShwartzDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Judith AgudoDepartment of Immunology, Harvard Medical School, Boston, MA 02215, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Ludwig Center at Harvard, Boston, MA 02215, USA; Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Ruth A FranklinDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Immunology, Harvard Medical School, Boston, MA 02215, USA.
Ya-Chieh HsuDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Biology of Adversity Project, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: yachieh_hsu@harvard.edu.

Funding

Rapid functional genetics to study stem cell-niche interactions in the skinR01AR080110 · NIAMS · HARVARD UNIVERSITY · PI Ya-Chieh Hsu · 2022 to 2026
$2.5M
Engineering dendritic cells to target islet antigen to pro-tolerogenic subsets for prevention and treatment of Type 1 DiabetesR01DK132544 · NIDDK · DANA-FARBER CANCER INST · PI Judith Agudo Cantero · 2022 to 2026
$2.2M
Aging and Rejuvenation of Skin Stem CellsR01AR083416 · NIAMS · HARVARD UNIVERSITY · PI Ya-Chieh Hsu · 2024 to 2026
$1.6M
Mechanisms of Fetal Skin RegenerationR01AR084566 · NIAMS · HARVARD UNIVERSITY · PI Ya-Chieh Hsu · 2024 to 2026
$1.4M
Nerve-stem cell interactions during skin homeostasis and wound repairF32AR079252 · NIAMS · HARVARD UNIVERSITY · PI SCOTT-SOLOMON, EMILY RIVKAH · 2021 to 2023
$205k
Interrogating the role of IFNgamma in promoting metastasis and immune evasion of triple negative breast cancerF32CA298459 · NCI · DANA-FARBER CANCER INST · PI Adam Joshua Getzler · 2025 to 2026
$155k
Defining Sexual Dimorphism in the SkinF31AR083715 · NIAMS · HARVARD MEDICAL SCHOOL · PI FREEMAN, REBECCA JANE · 2024 to 2025
$80k
NCI NIH HHS F32 CA298459NIAMS NIH HHS F31 AR083715NIAMS NIH HHS F32 AR079252NIAMS NIH HHS R01 AR080110NIAMS NIH HHS R01 AR083416NIAMS NIH HHS R01 AR084566NIDDK NIH HHS R01 DK132544
6 · The paper itself

Abstract

Stress has profound effects on health, yet how it damages tissues remains poorly understood. Here, we show that acute stress triggers rapid hair loss and initiates autoimmunity. Under stress, hyperactivated sympathetic nerves release excessive norepinephrine, causing necrosis in rapidly dividing hair follicle transit-amplifying cells (HF-TACs) while sparing most hair follicle stem cells (HFSCs). This differential sensitivity stems from differences in cell death pathways, metabolic strategies, and calcium homeostasis, which render HF-TACs more susceptible to norepinephrine-induced calcium surges. HF-TAC necrosis releases cellular debris that triggers macrophage-mediated clearance and dendritic cell activation, ultimately leading to the activation and amplification of autoreactive T cells that can attack the hair follicle under inflammatory insults. Our findings reveal mechanistically how stress causes immediate tissue damage in highly proliferative HF-TACs via sympathetic nerve-induced necrosis, which in turn fuels the activation of autoreactive T cells capable of mounting future attacks against the same tissue.

Indexed as

AutoimmunityHair FollicleStress, PhysiologicalSympathetic Nervous SystemAlopeciaAnimalsCalciumDendritic CellsFemaleMacrophagesMaleMiceMice, Inbred C57BLNecrosisNorepinephrineStem CellsCalciumNorepinephrinealopecia areataautoimmunenecrosisnerve-tissue interactionneuro-immune interactionstresssympathetic neuron

Identifiers

PMID41308637
PMCPMC12668284

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.