ArticleBasic & clinical pharmacology & toxicology2025
Effect of Bariatric Surgery on the Pharmacokinetics of Codeine, Oxycodone and Tramadol-A Case Series.
Article in Basic & clinical pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effect of Bariatric Surgery on the Pharmacokinetics of Codeine, Oxycodone and Tramadol-A Case Series.Basic & clinical pharmacology & toxicology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe impact of bariatric surgery on the pharmacokinetics of codeine, oxycodone or tramadol is largely unknown.
methodsIn patients treated with these opioids before and after bariatric surgery, serial drug concentrations were measured throughout a dose interval preoperatively and 1, 6 and 12 months postoperatively.
resultsEight patients treated with codeine (n = 2), oxycodone (n = 2) or tramadol (n = 4) were included. In the patients using codeine, the area under the concentration-time curve during a dose interval (AUC) was moderately increased for the active metabolites morphine and morphine 6-glucuronide 6-12 months after bariatric surgery. For oxycodone, there were only negligible AUC changes. In the tramadol group, there were no discernible AUC changes considered to be caused by the surgical procedure. There were no apparent changes in maximum concentrations or times to achieve maximum concentrations after surgery for any of the drugs or their metabolites.
conclusionFrom a pharmacokinetic point of view, we found no evidence that particular follow-up procedures should be needed for codeine, oxycodone and tramadol in patients undergoing bariatric surgery and continuing drug treatment. However, as always, doses should be adjusted based on clinical effect and the occurrence of adverse drug reactions.
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