SynthesisTranslational psychiatry2025
The evolving etiologies of rapidly progressive dementia: a systematic review.
Synthesis in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Atypical Alzheimer disease: a multi-axis framework toward defining heterogeneity.Nature reviews. Neurology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
background and purposeRapidly progressive dementia (RPD) represents a heterogeneous group of clinical dementia syndromes characterized by a precipitous decline in cognitive function, typically occurring over weeks to months, with diverse underlying etiologies. To elucidate the evolving etiological spectrum of RPD and investigate temporal trends, we conducted a comprehensive systematic review incorporating temporal subgroup analyses.
methodEnglish-language studies published prior to December 31, 2024 were searched in the Medline (PubMed), ISI Web of Science and the Cochrane Library databases. Study design, study period, patient characteristics, etiologies of RPD in each study were retrieved.
resultWe encompassed 13 studies in our final systematic review, involving a total of 1,701 patients with RPD. Our findings revealed that neurodegenerative diseases (459 cases, 27.0%), neuroimmune diseases (327 cases, 19.2%), and central nervous system infections (295 cases, 17.3%) represented the most prevalent etiological categories associated with RPD. Among distinct disease entities, autoimmune encephalitis (AE, 266 cases, 15.6%), Alzheimer's disease (214 cases, 12.6%), and Creutzfeldt-Jakob disease (214 cases, 12.6%) were identified as the three most frequently observed etiologies of RPD. Temporally, neuroimmune diseases, particularly AE, exhibited a significant upward trend in prevalence over the study period.
conclusionThese findings highlight the evolving etiological spectrum of RPD and emphasize the need for ongoing research and targeted diagnostic strategies to address the rising incidence of neuroimmune-related RPD.
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