Evidence map›Paper›PMID 41309604›Full record

ArticleNature communications2025

Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies.

Yue Ren, Mark R Segal, Tariq Shafi, Alexander R Pico, Min-Gyoung Shin, Michela Traglia, Hongzhe Li, Sylvia E Rosas, Hernan Rincon Choles, Panduranga S Rao and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yue RenDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1856-8633
Mark R SegalDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Tariq ShafiDivision of Nephrology, Baylor Scott White, Temple, TX, USA.
Alexander R PicoInstitute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA.
Min-Gyoung ShinInstitute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA.
Michela TragliaInstitute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA.
Hongzhe LiDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-3662-3907
Sylvia E RosasJoslin Diabetes Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Hernan Rincon CholesDepartment of Kidney Medicine, Medical Specialty Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0003-3559-4374
Panduranga S RaoDivision of Nephrology, University of Michigan, Ann Arbor, MI, USA.
Zeenat BhatDivision of Nephrology, University of Michigan, Ann Arbor, MI, USA.
Amanda H AndersonDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jing ChenDivision of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jiang HeSchool of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8286-9652
Steven SozioJohns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-0099-0484
Bernard JaarJohns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA.
Michelle M EstrellaKidney Health Research Collaborative, University of California San Francisco and San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
Wei ChenDivision of Nephrology, Albert Einstein College of Medicine, Bronx, NY, USA.
Glenn M ChertowDepartments of Medicine, Epidemiology and Population Health, and Health Policy, Stanford University School of Medicine, Stanford, CA, USA.
Rulan S ParekhDivision of Nephrology, Women's College Hospital, Toronto, ON, Canada.
Peter GanzDivision of Cardiology, University of California, San Francisco, CA, USA.ORCID 0000-0002-0437-8882
Ruth F DubinDivision of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA. ruth.dubin@utsouthwestern.edu.ORCID 0000-0002-0498-1980
CRIC Study Investigators

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Scientific and Data Coordinating Center(SDCC) for the P*U01DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2001 to 2017
$50.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3M
Continuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) StudyU24DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Amanda Hyre Anderson, Laura M Dember · 2018 to 2026
$21.5M
Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI WATSON, DOUGLAS · 2002 to 2009
$20.2M
Study of the Care and Outcomes of REnal InsufficiencyU01DK060902 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2001 to 2025
$19.5M
Limited Competition for the Continuation of the Chronic Renal Insufficiency CohorU01DK061021 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RAHMAN, MAHBOOB · 2001 to 2025
$17.3M
Prospective Renal Insufficiency Cohort Evaluation:PRICEU01DK060984 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI COHEN, DEBBIE L · 2001 to 2025
$17.0M
NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UM1 TR004528NCRR NIH HHS M01 RR016500NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR029879NHLBI NIH HHS R01 HL153499NIDDK NIH HHS R01 DK072367NIDDK NIH HHS R01 DK119199NIDDK NIH HHS U01 DK060902NIDDK NIH HHS U01 DK060963NIDDK NIH HHS U01 DK060980NIDDK NIH HHS U01 DK060984NIDDK NIH HHS U01 DK060990NIDDK NIH HHS U01 DK061021NIDDK NIH HHS U01 DK061022NIDDK NIH HHS U01 DK061028NIDDK NIH HHS U24 DK060990NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

More than 50% of patients with kidney failure undergoing maintenance hemodialysis die within 5 years, a fate unexplained by traditional risk factors. To identify biological risk factors, we analyze 6287 circulating proteins and mortality in 893 participants undergoing hemodialysis in the Chronic Renal Insufficiency Cohort (CRIC) and Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease (PACE) studies. Proteins are measured shortly after (incident period) and one year after (prevalent period) dialysis initiation. In CRIC prevalent period, Sushi von Willebrand factor type A EGF and pentraxin domain-containing protein 1(SVEP1), R-spondin 4, tetranectin and 24 other proteins attain Bonferroni significance (p < 7 × 10

Indexed as

Kidney Failure, ChronicProteomicsRenal DialysisAdultAgedBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsBiomarkers

Identifiers

PMID41309604
PMCPMC12749766

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.