Recalled childhood trauma and post-psychedelic trajectories of change in a mixed-methods study.

This mixed-methods study examines how participant-identified childhood or youth trauma resurfaces during psychedelic states and how such episodes relate to post-experience trajectories. Including events participants identified as traumatic during psychedelic experiences, and subsequent psychological outcomes, both positive and negative. While psychedelics can facilitate emotional processing of autobiographical material, a minority experience adverse effects or re-traumatization when trauma resurfaces. Phase 1 surveyed 608 individuals who experienced post-psychedelic difficulties lasting beyond acute effects. Those who reported that their post-psychedelic difficulties seemed to be related to early trauma (41.8%) were significantly older, more often female, were more likely to report a prior mental-illness diagnosis, and were more likely to use psychedelics in guided settings compared to those who did not. They also reported significantly more emotional difficulties but fewer perceptual difficulties after the experience. Phase 2 involved semi-structured interviews with 18 purposively selected participants. Reflexive thematic analysis identified four themes describing how trauma surfaced during psychedelic experiences: direct trauma re-experiencing (39% of participants, including some with no prior memory of events), symbolic/somatic re-embodiment (22%), and fragmentation and confusion (50%). A fourth theme captured varied post-experience trajectories, ranging from predominantly positive integration (50%) to mixed effects (28%) to re-traumatization (22%). The study highlights uncertainty around memory veridicality as a source of ongoing distress for some participants. Findings emphasize the critical need for trauma-informed approaches to psychedelic use, stressing appropriate preparation, supportive settings, and robust integration support to maximize therapeutic potential while preventing re-traumatization.