ArticleScientific reports2025
Charlson index predicts thirtyday mortality in critically ill stroke patients MIMICIV retrospective study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Hospital Cost Components and Predictors inTropical medicine and infectious disease · 2026Article
- Predictors of adult ICU mortality: a retrospective study at two government hospitals in Ethiopia.Scientific reports · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke, characterized by disrupted cerebral blood flow and neuronal damage, poses a significant risk of mortality. Using the MIMIC-IV data, we investigated the association between the Charlson Comorbidity Index (CCI) and 30-day mortality in critically ill patients with stroke. Our analysis showed that each unit increase in CCI raised mortality risk by 12% (HR = 1.12, 95% CI = 1.09-1.16, P < .001). Subgroup analysis indicated no demographic interactions (P > .05), and sensitivity analyses confirmed the robustness of the findings across the models. Systematic CCI evaluation may enhance risk stratification and clinical management in critical stroke care. This study highlights that higher CCI scores correlate with increased post-stroke mortality risk, underscoring the value of CCI in clinical risk assessment. However, these limitations include the vulnerability of the retrospective design to residual confounding and the exclusion of nutritional metrics (e.g., BMI) due to over 50% missing data. Despite these limitations, the incorporation of CCI assessments can improve the outcomes.
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