Evidence map›Paper›PMID 41309840›Full record

ArticleScientific reports2025

Impact of dietary Phyllanthus emblica on growth, immunity, antioxidant capacity, and Fusarium oxysporum resistance in red tilapia.

Roshmon Thomas Mathew, Yousef Ahmed Alkhamis, Ahmed Saud Alsaqufi, Abdallah Tageldein Mansour, Hesham S Ghazzawy, Nagarajan Ganesan, Moaheda E H Eissa, Zulhisyam Abdul Kari, Ehab El-Haroun, Kasim Sakran Abass and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roshmon Thomas MathewFish Resources Research Center, King Faisal University, Al-Ahsa, 31982, Saudi Arabia. rmathew@kfu.edu.sa.
Yousef Ahmed AlkhamisAnimal and Fish Production Department, College of Agricultural and Food Sciences, King Faisal University, Hofuf-420, Al-Ahsa, 31982, Saudi Arabia.
Ahmed Saud AlsaqufiAnimal and Fish Production Department, College of Agricultural and Food Sciences, King Faisal University, Hofuf-420, Al-Ahsa, 31982, Saudi Arabia.
Abdallah Tageldein MansourAnimal and Fish Production Department, College of Agricultural and Food Sciences, King Faisal University, Hofuf-420, Al-Ahsa, 31982, Saudi Arabia.
Hesham S GhazzawyDate Palm Research Center of Excellence, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.
Nagarajan GanesanDepartment of Basic Sciences, Preparatory Year, King Faisal University, P.O. Box 400, Al‑Ahsa, 31982, Saudi Arabia.
Moaheda E H EissaBiotechnology Department, Fish Farming and Technology Institute, Suez Canal University, Ismailia 41522, Egypt. moahedaelsayed@gmail.com.ORCID https://orcid.org/0000-0002-1733-6892
Zulhisyam Abdul KariDepartment of Agricultural Sciences, Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, Jeli Campus, Jeli , 17600, Kelantan, Malaysia.
Ehab El-HarounDepartment of Integrative Agriculture, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates. ehab.reda@uaeu.ac.ae.
Kasim Sakran AbassDepartment of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Kirkuk, Kirkuk, 36001, Iraq.
Prasob-Orn RinthongPharmaceutical Chemistry and Natural Product Research Unit, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, 44150, Thailand.
El-Sayed Hemdan EissaFish Research Centre, Faculty of Environmental Agricultural Sciences, Arish University, El-Arish, Egypt.ORCID https://orcid.org/0000-0002-7229-2175

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying natural growth-promoting agents and implementing environmentally sustainable methodologies are paramount strategies for enhancing the performance and welfare of aquatic fish farms. Phyllanthus emblica (PE) possesses a broad spectrum of bioactive properties, including antioxidant, antiviral, antimicrobial, and immunomodulatory effects. Hence, this study aimed to investigate the beneficial effects of PE dietary supplementation on the growth, immunity, redox homeostasis, organ histology, gene transcripts, and disease resistance of Red Tilapia against Fusarium oxysporum. A total of 240 fish (25.0 ± 3.0 g) were randomly distributed among 12 ponds, with 20 fish per pond. The fish were fed a basal diet supplemented with 0 (PE0), 5 (PE5), 10 (PE10), or 20 g of PE powder per kg of diet for 70 days. Following the trial, a challenge test was carried out. The PE5 group achieved significantly greater body weight, weight gain, specific growth rate (SGR) and digestive enzymes (lipase and amylases) than the PE20 group (p < 0.05). However, the PE5 group recorded the best feed conversion ratio compared to the other groups (p < 0.05). All PE-supplemented groups exhibited lower muscle lipid content and higher ash content (p < 0.05). PE-fortified groups displayed substantially lower levels of liver enzymes (AST, ALT, and ALP), creatinine, glucose, and lipid profile (cholesterol, triglycerides) compared to the PE0 group (p < 0.05). PE-fortified diets significantly enhanced the fish's antioxidant enzyme activities (SOD, CAT, and GPx), immunological parameters (p < 0.05) for phagocytic activity, phagocytic index, and WBCs) and preserved the intestinal and hepatic tissues. The supplementation of 5 g PE/kg in Red Tilapia significantly enhanced the gene expression of growth genes (GH and IGF-1). In contrast, the group supplemented with 20 g PE/kg showed superior results for immune-related genes (including CC chemokines and interleukin-8) and antioxidant enzymes (SOD and GPx) (p < 0.05). Overall, the inclusion of 5 g/kg PE optimized growth performance in Red Tilapia, while the inclusion of 20 g/kg resulted in superior immune and antioxidant capabilities. These results highlight PE's dual potential to enhance growth and boost health, confirming its promise as a natural feed additive for sustainable Tilapia aquaculture.

Indexed as

AntioxidantsDisease ResistanceFish DiseasesFusariumPhyllanthus emblicaTilapiaAnimal FeedAnimalsDietDietary SupplementsAntioxidantsBlood healthFusarium oxysporumGrowth promotersImmunity and antioxidantRed tilapia

Identifiers

PMID41309840
PMCPMC12660688

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.