Evidence map›Paper›PMID 41310074›Full record

ReviewHypertension research : official journal of the Japanese Society of Hypertension2026

Overcoming variable response in renal denervation: Key strategies for reliable clinical implementation.

Xianghao Zuo, Yao Xiao, Zhipeng Zhang, Jiaxuan Xie, Fang Wang, Kai Wu, Qin Xi, Yong Peng, Kai Liu, Xiaoping Chen

Abstract readReview
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In one paragraph

Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xianghao Zuo *Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yao Xiao *Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Zhipeng ZhangDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Jiaxuan XieDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Fang WangEchocardiography Room, Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Kai WuDepartment of Cardiovascular Medicine, Sichuan Science City Hospital, Mianyang, Sichuan, 621000, China.
Qin XiDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Yong PengDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Kai LiuDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. liukaicardiology@wchscu.edu.cn.
Xiaoping ChenDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While renal denervation (RDN) represents a promising therapy for resistant hypertension, substantial heterogeneity in blood pressure-lowering efficacy and a significant treatment non-response rate (reaching up to one-third of cases) impede its broader clinical adoption. This variability likely arises from two primary sources: interindividual differences in sympathetic nervous system activation among hypertensive patients (the pathological substrate for ablation) and procedural limitations ("black-box procedure") leading to incomplete sympathetic denervation. Our comprehensive review synthesizes recent advances in precision patient selection and procedural refinement for RDN. Furthermore, we propose a conceptual framework aimed at enhancing therapeutic consistency through the integrated optimization of patient stratification and ablation techniques. We believe this work provides insights to support the reliable clinical translation of RDN. Key strategies to improve treatment response to RDN. Notes: RDN, renal denervation; HR, heart rate; BRS, baroreflex sensitivity; PWV, pulse wave velocity; AASI, arterial stiffness index; TAC, total arterial compliance; RNS, renal nerve stimulation.

Indexed as

HypertensionKidneySympathectomyBaroreflexBlood PressureHumansSympathetic Nervous SystemTreatment OutcomeAortorenal Ganglion AblationHypertensionRenal denervationRenal nerve stimulationResponse rate

Identifiers

PMID41310074

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.