ArticleCommunications biology2025
Cell- and sex-specificity in the transcriptomic response of the hippocampal neurovascular unit to obesity.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, Wnt, and WISP1.Expert review of clinical pharmacology · 2026Review
- Running out the clock: Circadian rhythm dysfunction in cognitive disease.International review of neurobiology · 2026Review
- Sex differences in endothelial cell biology: cellular phenotypes and molecular regulators.Frontiers in physiology · 2026Review
- Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways.Aging advancesArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Obesity is a risk factor for vascular dementia and exhibits sex differences in comorbidities and prevalence. However, its cell-specific effects on the neurovascular unit (NVU) remain unknown. Here we show, using the ob/ob mouse model and single nuclei RNA sequencing, how obesity modulates the hippocampal NVU transcriptome in females. Obesity alters endothelial-specific differentially expressed genes (DEGs) involved in angiogenesis and blood brain barrier permeability. DEGs in common between endothelial cells and other NVU cells are associated with neurotransmission and autophagy. Some gene expression changes from each NVU cell type correlate with behavioral changes. Sex-based analyses comparing to our previously reported male data indicate that the NVU transcriptomic response to obesity is modified by sex in a cell-type specific manner. Endothelial and microglial cells exhibit greater sex-specificity than astrocytes and neurons. The findings from our work may help inform both sex-independent and sex-specific approaches to prevention and treatment for obesity-related dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.