Evidence map›Paper›PMID 41310259›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model.

Shinya Yokomizo, Megi Maci, April M Stafford, Morgan R Miller, Stephen J Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown-Harding, Linda Liang, Alex Lovely and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Shinya YokomizoDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.ORCID https://orcid.org/0000-0003-4096-9695
Megi MaciDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.
April M StaffordDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, 49503, USA.
Morgan R MillerDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.
Stephen J PerleDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.
Shuzo InagakiDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.
Shusaku TakahashiDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.
Heather Brown-HardingDepartment of Molecular and Cellular Biology and Harvard Center for Biological Imaging, Harvard University, Cambridge, MA, 02138, USA.
Linda LiangDepartment of Molecular and Cellular Biology and Harvard Center for Biological Imaging, Harvard University, Cambridge, MA, 02138, USA.
Alex LovelyDepartment of Molecular and Cellular Biology and Harvard Center for Biological Imaging, Harvard University, Cambridge, MA, 02138, USA.
Moustafa AlgamalDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.
Rebecca L GillaniDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.
Theodore J ZwangDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.
Douglas RichardsonDepartment of Molecular and Cellular Biology and Harvard Center for Biological Imaging, Harvard University, Cambridge, MA, 02138, USA.
Janice R NaegeleDepartment of Biology, Program in Neuroscience and Behavior, Hall-Atwater Laboratory, Wesleyan University, Middletown, CT, 06459, USA.
Daniel VogtDepartment of Pediatrics and Human Development, Michigan State University, Grand Rapids, MI, 49503, USA.
Ksenia V KastanenkaDepartment of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Mass General Brigham and Harvard Medical School, Charlestown, MA, 02129, USA.ORCID https://orcid.org/0000-0002-3727-0317

Funding

Japan Agency for Medical Research and DevelopmentJapan Society for the Promotion of Science 202360054NIA NIH HHS R01 AG066171NIA NIH HHS R21 AG075807NIH HHS R01AG066171NIH HHS R21AG075807
6 · The paper itself

Abstract

In addition to dementia, Alzheimer's patients suffer from sleep impairments and aberrations in sleep-dependent brain rhythms. Deficits in inhibitory GABAergic interneuron function disrupt one of those rhythms, slow oscillation in particular, and actively contribute to Alzheimer's progression. The degree to which transplantation of healthy donor interneuron progenitors restores slow oscillation rhythm in young APP/PS1 mice is tested. Medial ganglionic eminence (MGE) progenitors are harvested from mouse embryos and transplanted them into host APP/PS1 mutant cortices. 3D light-sheet and structured illumination microscopy revealed that transplanted MGE progenitors survived and matured into healthy interneurons. In vivo multiphoton calcium imaging and voltage-sensitive dye imaging showed functional integration and slow oscillation rescue in the absence or presence of optogenetic stimulation. The work provides proof-of-concept evidence that stem cell therapy may serve as a viable strategy to rescue functional impairments in cortical circuits of APP/PS1 mice and potentially those of Alzheimer's patients.

Indexed as

Alzheimer DiseaseCerebral CortexGABAergic NeuronsInterneuronsStem Cell TransplantationAnimalsDisease Models, AnimalMiceMice, TransgenicAlzheimer's diseaseGABAergic interneuronmedial ganglionic eminenceoptogeneticssleepstem‐cell–based therapytransplantation

Identifiers

PMID41310259
PMCPMC12904069

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.