Evidence map›Paper›PMID 41310263›Full record

ArticleGeroScience2026

Plasma biomarkers of alzheimer's disease and related dementias are associated with cognitive change in community-dwelling older individuals in Australia and the US.

Zimu Wu, Michelle M Mielke, Anne M Murray, Katherine Webb, Robyn L Woods, Alice Owen, Suzanne G Orchard, Trevor T-J Chong, Kerry M Sheets, Joanne Ryan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zimu WuSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC, 3004, Australia. zimu.wu1@monash.edu.
Michelle M MielkeDepartment of Epidemiology and Prevention, School of Medicine, Wake Forest University, 475 Vine Street, Winston-Salem, NC, 27101, USA.
Anne M MurrayDivision of Geriatric and Palliative Medicine, Department of Medicine, Hennepin Healthcare, 701 Park Avenue, Minneapolis, MN, 55404, USA.
Katherine WebbSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC, 3004, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC, 3004, Australia.
Alice OwenSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC, 3004, Australia.
Suzanne G OrchardSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC, 3004, Australia.
Trevor T-J ChongTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia.
Kerry M SheetsDivision of Geriatric and Palliative Medicine, Department of Medicine, Hennepin Healthcare, 701 Park Avenue, Minneapolis, MN, 55404, USA.
Joanne RyanSchool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC, 3004, Australia. joanne.ryan@monash.edu.

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
Sex-specific risk factors and trajectories of blood biomarkers for Alzheimer's disease and related dementiasR01AG079397 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI ANNE M MURRAY, Michelle M Mielke · 2025 to 2026
$1.0M
National Health and Medical Research Council 1127060National Health and Medical Research Council 1135727National Health and Medical Research Council 334047NIA NIH HHS 1RF1AG079397NIA NIH HHS R01 AG079397NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682NINR NIH HHS U01AG029824NINR NIH HHS U19AG062682
6 · The paper itself

Abstract

Plasma biomarkers of Alzheimer's disease and related dementias (ADRD) are associated with the risk of dementia. However, the extent to which they could reflect cognitive ageing, and whether this is consistent across factors known to influence biomarkers (e.g. sex and chronic kidney disease) and in different populations, is unknown. Data were from a diverse community-dwelling cohort of older individuals without dementia in Australia (n = 11,930) and the US (n = 1,181). Global cognition, verbal fluency, episodic memory and psychomotor speed were assessed repeatedly over more than a decade. Plasma phosphorylated tau181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL) and amyloid beta (Aβ) 42 and 40 were measured using Simoa technology. Higher levels of p-tau181 (β: -0.001 to -0.212), GFAP (β: -0.022 to -0.300) and NfL (β: -0.022 to -0.219), and lower levels of Aβ42/40 ratio (β: 0.015 to 0.126) were associated with greater cognitive decline over time. Associations were strongest for global cognition, episodic memory, and psychomotor speed, and weaker/non-significant for verbal fluency. All associations were consistent across countries. Furthermore, in stratified analyses, the results did not differ by sex or depending on the presence of chronic kidney disease. We found robust associations between plasma ADRD biomarkers and cognitive change in initially healthy older individuals in both Australia and the US, and across both sexes. Despite chronic kidney disease influencing biomarker levels, associations were consistent among individuals with and without chronic kidney disease. This indicates the potential broad utility of these biomarkers.

Indexed as

Alzheimer DiseaseDementiaAgedAged, 80 and overAmyloid beta-PeptidesAustraliaBiomarkersCognitionFemaleGlial Fibrillary Acidic ProteinHumansIndependent LivingMaleNeurofilament ProteinsPeptide Fragmentstau ProteinsAmyloid beta-PeptidesBiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau ProteinsAlzheimer’s disease and related dementiasAmyloid betaCognitive functionGlial fibrillary acidic proteinNeurofilament light chainPhosphorylated tau181

Identifiers

PMID41310263
PMCPMC12972394

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.