Evidence map›Paper›PMID 41310281›Full record

ReviewNature neuroscience2026

An adaptive and flexible role for primary sensory cortex.

Christian Waiblinger, April R Reedy, Garrett B Stanley

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Brain-wide activity mapping reveals the somatosensory cortex as a sex-specific regulator of hedonic feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christian WaiblingerWallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-9763-3693
April R ReedyIntegrated Cellular Imaging Core, Emory University School of Medicine, Emory University, Atlanta, GA, USA.
Garrett B StanleyWallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. garrett.stanley@bme.gatech.edu.ORCID http://orcid.org/0000-0003-2039-7706

Funding

Thalamocortical state control of tactile sensing: Mechanisms, Models, and BehaviorR01NS104928 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI STANLEY, GARRETT B. · 2018 to 2022
$2.1M
Feedback and feedforward gating of sensory signaling through timing in the thalamocortical loopRF1NS128896 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI STANLEY, GARRETT B. · 2022 to 2022
$1.6M
Crossing space and time: uncovering the nonlinear dynamics of multimodal and multiscale brain activityR01EB029857 · NIBIB · EMORY UNIVERSITY · PI KEILHOLZ, SHELLA D, STANLEY, GARRETT B. · 2020 to 2021
$1.3M
U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB029857U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS104928U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RF1NS128896
6 · The paper itself

Abstract

Classical views of sensory perception describe a hierarchical organization, extending from the sensory periphery to static representations in the primary sensory cortex, with downstream regions supporting decision-making and action. There is growing evidence that suggests a more flexible role of primary sensory cortex, with behaviorally relevant functions distributed across multiple levels of the early sensory pathway that can change in response to context. In this Perspective, we first examine primary sensory cortex beyond sensory representations through the lens of sufficiency to predict behavior. We then consider the necessity of primary sensory cortex in sensory-driven behaviors, explored through a range of inactivation and lesioning studies. Finally, we provide evidence that points to an adaptive and flexible role for primary sensory cortex, where function is shaped by experience and context. This adaptive nature demands a more holistic investigative approach that challenges sensory pathways with adaptive behaviors in response to changing environments, behavioral contexts and injury.

Indexed as

Adaptation, PhysiologicalSomatosensory CortexAnimalsHumans

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.