Evidence map›Paper›PMID 41310285›Full record

ArticleLangenbeck's archives of surgery2025

Complications following upfront pancreatectomy with venous resection do not compromise adjuvant chemotherapy delivery and survival in pancreatic cancer.

Giampaolo Perri, Samuele Grandi, Muyue Liu, Riccardo Pellegrini, Jianzhen Lin, Nicola Canitano, Riccardo Guastella, Zipeng Lu, Domenico Bassi, Umberto Cillo and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giampaolo Perri *Hepato-pancreato-biliary and Liver Transplant Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Via Giustiniani 2, Padua, 35128, Italy. giampaolo.perri@unipd.it.
Samuele Grandi *Hepato-pancreato-biliary and Liver Transplant Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Via Giustiniani 2, Padua, 35128, Italy.
Muyue LiuPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Institute of Pancreas, Nanjing Medical University, Nanjing, China.
Riccardo PellegriniHepato-pancreato-biliary and Liver Transplant Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Via Giustiniani 2, Padua, 35128, Italy.
Jianzhen LinPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Institute of Pancreas, Nanjing Medical University, Nanjing, China.
Nicola CanitanoHepato-pancreato-biliary and Liver Transplant Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Via Giustiniani 2, Padua, 35128, Italy.
Riccardo GuastellaHepato-pancreato-biliary and Liver Transplant Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Via Giustiniani 2, Padua, 35128, Italy.
Zipeng LuPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Institute of Pancreas, Nanjing Medical University, Nanjing, China.
Domenico BassiHepato-pancreato-biliary and Liver Transplant Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Via Giustiniani 2, Padua, 35128, Italy.
Umberto CilloHepato-pancreato-biliary and Liver Transplant Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Via Giustiniani 2, Padua, 35128, Italy.
Kuirong JiangPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Institute of Pancreas, Nanjing Medical University, Nanjing, China.
Giovanni MarchegianiHepato-pancreato-biliary and Liver Transplant Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Via Giustiniani 2, Padua, 35128, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe combined burden of vascular resections and pancreas-specific complications may preclude or delay adjuvant chemotherapy and impair survival. We evaluated the effect of complications on adjuvant therapy delivery and survival after upfront pancreatectomy with venous resection (PVR).

methodsPatients undergoing upfront PVR were retrieved from a prospectively maintained database at two high-volume Institutions. The incidence and severity of complications were correlated with administration of adjuvant chemotherapy and overall survival.

resultsOverall, 280 patients underwent upfront PVR. 75% (N = 210) underwent pancreatoduodenectomy (PD), 15% (N = 41) distal pancreatectomy (DP), and 10% (N = 29) total pancreatectomy (TP). Major morbidity occurred in 34% (N = 96), with 4% (N = 12) 90-day mortality. Overall rates of POPF, PPH, and DGE were 22%, 15%, and 18%, respectively. Mortality was higher in Type IV venous resections (14%, p = 0.028). DP was associated with higher morbidity but similar mortality compared to PD and TP. The only factor independently associated with adjuvant chemotherapy delivery, administered in 196 (70%), was ASA score < 3 (p = 0.003). Factors independently associated to worse OS were age > 75 years, TP, pT > 2, pN2, and lack of adjuvant chemotherapy delivery.

conclusionsUpfront PVR has an acceptable risk profile and oncologic outcomes when adjuvant chemotherapy is administered. Survival and the delivery of adjuvant therapy do not appear to be negatively affected by complications.

Indexed as

Carcinoma, Pancreatic DuctalPancreatectomyPancreatic NeoplasmsPancreaticoduodenectomyPostoperative ComplicationsVeinsAgedAge FactorsChemotherapy, AdjuvantFemaleHospital MortalityHumansKaplan-Meier EstimateMaleMiddle AgedPancreasCancerChemotherapyPancreatectomyResectionVein

Identifiers

PMID41310285
PMCPMC12743065

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.