ReviewCell biology and toxicology2025
Molecular mechanisms in diquat-induced organs injury：insights into cell signaling and potential therapeutic agents.
Review in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Ubiquitylome analysis reveals the protective effect of α-lipoic acid via the ferroptosis pathway during recovery after hepatic oxidative stress in finishing pigs.Stress biology · 2026Article
- A dual-function host-guest antioxidant system for synergistic treatment of diquat poisoning.RSC advances · 2026Article
- Effect of yeast selenium on autophagy and PINK1/Parkin expression in Diquat-induced chicken liver and kidney cells.Poultry science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Diquat (DQ) is a potent, non-selective herbicide which can result in severe poisoning and a high mortality if ingested accidentally or intentionally. Diquat poisoning can cause extensive damage to multiple organs, including the intestines, liver, kidneys, brain, and other organs. As there are no specific antidotes available for DQ poisoning, the current therapeutic strategies are essentially restricted to blood purification therapy and supportive care. Numerous studies on the molecular mechanisms and potential therapeutic agents have been conducted over the past few decades. However, there has been no comprehensive summary or analysis of these findings. This review extensively investigates the molecular mechanisms underlying DQ-induced organ injury, with a particular focus on the major signaling pathways. In addition, searches were conducted in PubMed and Web of Science using the following search terms: "diquat"[tiab] OR "diquat"[MeSH Terms]. A total of 166 eligible papers published over the past 35 years were selected. Consequently, more than seventy potential therapeutic agents with protective effects against DQ-induced toxicity are summarized and analyzed. In the future, it will be essential to conduct preclinical research and clinical trials to extrapolate these findings to humans.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.