ArticleBMC microbiology2025
Alistipes putredinis CCUG 45780
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Metabolic shifts driven by host-microbial interactions.The FEBS journal · 2026Review
- Nervonic Acid Prevents HFD-Induced Metabolic Dysfunction and Is Associated with Gut Microbiota Remodeling.Metabolites · 2026Article
- Electroacupuncture prevents CUMS induced depressive-like behaviors by inhibiting microglia-mediated synaptic pruning induced by gut dysbiosis.Chinese medicine · 2026Article
- Effects of Exposure to Extreme Artificial Light at Night on Liver Oxidative Damage and Gut Microbiota During Pregnancy and Lactation in Mice.Animals : an open access journal from MDPI · 2026Article
- Phenolamide Extract of Apricot Bee Pollen Alleviates DSS-Induced Ulcerative Colitis in Mice by Reducing Oxidative Stress, Modulating Inflammation, and Regulating Gut Microbiota.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAlistipes is a relatively new genus in the phylum Bacteroidetes, and its role in UC remains unclear. Among its members, Alistipes putredinis is particularly prominent. In this study, we investigated the effects of Alistipes putredinis CCUG 45780
resultsWhole-genome sequencing of Alistipes putredinis CCUG 45780ᵀ revealed 13 virulence genes and 11 resistance genes. Targeted metabolomic analysis identified 9 metabolites significantly increased in the bacterial culture supernatant, among which only succinate exhibited proinflammatory effects. Oral administration of Alistipes putredinis CCUG 45780ᵀ did not cause overt pathogenicity in healthy mice but significantly exacerbated DSS-induced colitis, as indicated by weight loss, elevated disease activity index (DAI) scores, colon shortening, and aggravated mucosal damage. This was accompanied by markedly increased expression of TNF-α, IL-1β, IL-6, and NLRP3. Moreover, treatment altered the gut microbial community, increasing Bacteroidetes abundance while reducing Actinobacteria and Lactobacillus, elevated colonic succinate levels, and upregulated SUCNR1 expression. Collectively, these findings suggest that Alistipes putredinis CCUG 45780ᵀ aggravates colitis through microbiota modulation and succinate-mediated inflammation.
conclusionAlistipes putredinis CCUG 45780ᵀ exacerbates DSS-induced colitis in mice, likely through gut microbiota dysregulation and succinate-driven inflammatory pathways.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.