Evidence map›Paper›PMID 41310426›Full record

ArticleBMC genomics2025

Remarkable heterogeneity revealed in the genetic architecture of resistance to a key bacterial pathogen in two commercial rainbow trout populations.

Simon Pouil, Dimitri Rigaudeau, Bo-Hyung Lee, Emilien Segret, Alexandre Desgranges, Jonathan D'Ambrosio, Yoannah François, Pierre Boudinot, Eric Duchaud, Florence Phocas and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Simon PouilUniversité Paris-Saclay, INRAE, AgroParisTech, GABI, Domaine de Vilvert, Jouy-en-Josas, 78350, France. simon.pouil@inrae.fr.
Dimitri RigaudeauUniversité Paris-Saclay, IERP, INRAE, Jouy-en-Josas, 78350, France.
Bo-Hyung LeeUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78350, France.
Emilien SegretViviers de Sarrance, Sarrance, 64490, France.
Alexandre DesgrangesLes Aquaculteurs Bretons, Morlaix, 29678, France.
Jonathan D'AmbrosioSYSAAF Section Aquacole, Campus de Beaulieu, Rennes, 35000, France.
Yoannah FrançoisSYSAAF Section Aquacole, Campus de Beaulieu, Rennes, 35000, France.
Pierre BoudinotUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78350, France.
Eric DuchaudUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78350, France.
Florence Phocas *Université Paris-Saclay, INRAE, AgroParisTech, GABI, Domaine de Vilvert, Jouy-en-Josas, 78350, France.
Tatiana Rochat *Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78350, France.

Funding

European Maritime and Fisheries Fund and France AgriMer Flavocontrol project, n° PFEA470020FA1000004
6 · The paper itself

Abstract

backgroundBacterial cold-water disease (BCWD), caused by Flavobacterium psychrophilum, remains a major challenge for rainbow trout (Oncorhynchus mykiss) aquaculture, due to the absence of effective vaccines and increasing concerns over antibiotic use. Genetic selection for disease resistance offers a sustainable alternative. In this study, we investigated the genetic architecture of BCWD resistance in two French commercial rainbow trout populations using a standardized waterborne infection model and high-density SNP genotyping.

resultsSurvival following experimental infection varied significantly between populations, with population B showing higher resistance (71.3% vs. 50.7% of survival at 29 days post-infection). Genome-wide association studies (GWAS) were performed using a Bayesian sparse linear mixed model (BSLMM), separately in each population and in a combined dataset. Eleven quantitative trait loci (QTLs) were identified across the analyses, with limited overlap between populations, highlighting the complexity and partial divergence of resistance architectures. Several candidate genes located within QTL regions were involved in immune signalling, inflammation, macrophages/neutrophils biology, and soluble factors important for antibacterial defences. Notably, two QTLs contained genes from the complement system (e.g., C3, Cfb), highlighting their central role in resistance to F. psychrophilum.

conclusionsOur findings underscore the polygenic nature of BCWD resistance, the influence of host genetic background, and provide valuable targets for selection for BCWD resistance in rainbow trout breeding programs.

Indexed as

Disease ResistanceFish DiseasesFlavobacteriaceae InfectionsFlavobacteriumGenetic HeterogeneityOncorhynchus mykissAnimalsBayes TheoremGenome-Wide Association StudyPolymorphism, Single NucleotideQuantitative Trait LociAntibacterial responseAquacultureBath infectionBCWDFlavobacterium psychrophilumOncorhynchus mykissQTLResistance to pathogens

Identifiers

PMID41310426
PMCPMC12809949

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.