ArticleBMC geriatrics2025
The relationship between disability, anxiety and depression in older adults with chronic disease comorbidities: the mediating role of frailty.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Latent pain class identification, longitudinal transitions, and machine learning prediction of incident low back pain in middle-aged and older Chinese adults.BMC medical informatics and decision making · 2026Article
- Article
- Burden and Risk Factors of Neck Pain in China: A Dual-Database Study of GBD 2021 Population-Level Macro-Trends and CHARLS Individual-Level Prospective Cohort Analyses.Journal of pain research · 2026Article
- Myofascial pain in older adults: a geroscience-informed framework integrating precision geriatrics and digital therapeutics.Frontiers in aging neuroscience · 2026Review
- Digital health technology empowering China's community full life cycle health management.Digital healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundThe global aging crisis has intensified concerns about disability, frailty, anxiety, and depression in older adults, particularly those with multimorbidity. However, the interrelationships among these factors remain not fully understood. This study investigates the mediating role of frailty between disability and anxiety/depression in this population.
methodsA cross-sectional study was conducted from October 2022 to January 2023, enrolling 4,372 older adults with multimorbidity from 3 tertiary hospitals, 5 secondary hospitals, and 3 community health centers in Zunyi, China. Data were collected using validated instruments: Activities of Daily Living (ADL), the Self-Rating Anxiety Scale (SAS), Generalized Anxiety Disorder-7 (GAD-7), Geriatric Depression Scale-Short Form (GDS-15), and Frailty Phenotype. Spearman correlation, binary logistic regression, and mediation analysis (SPSS PROCESS 3.5) with Bootstrap testing (5,000 resamples) were employed.
resultsAmong participants, 437 (10.0%) exhibited disability. Significant correlations were observed between disability and anxiety/depression (r = 0.32-0.41, p < 0.001). Frailty partially mediated the disability-anxiety (50.45% of total effect) and disability-depression (48.17%) relationships (p < 0.001).
conclusionFrailty serves as a critical mediator between disability, anxiety and depression in older adults with chronic disease comorbidity. Targeted interventions addressing disability and frailty may significantly mitigate anxiety and depression, thereby improving mental health and quality of life in this vulnerable population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.