Evidence map›Paper›PMID 41310770›Full record

ArticleBiology direct2025

NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway.

Qiaoyun Yang, Yani Shi, Wei Li, Xiaojing Xiong, Qingwei Chen, Minming Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiaoyun Yang *Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Yani Shi *Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Wei LiDepartment of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Xiaojing XiongDepartment of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Qingwei ChenDepartment of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. chenqwcq@163.com.
Minming ZhengDepartment of Ophthalmology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 304239@hospital.cqmu.edu.cn.

Funding

China Postdoctoral Science Foundation 2024M763897The Chongqing Municipal Health Commission Medical Research Project 2024WSJK097the National Natural Science Foundation of China 31871182The Natural Science Foundation of Chongqing City CSTB2023NSCQ-MSX0115The Postdoctoral Fellowship Program of CPSF GZC20242144Wellcome Trust 202228
6 · The paper itself

Abstract

backgroundPeripheral artery disease (PAD), caused by atherosclerosis resulting in reduced blood flow in the lower extremities, impairs both skeletal muscle mass and function in humans, and its molecular mechanism is not clear. Recent studies have demonstrated that Nicotinamide phosphoribosyl transferase (NAMPT) influences skeletal muscle mass and function by modulating NAD

resultsNAMPT is downregulated in ischemic skeletal muscle and CoCl

conclusionsNAMPT protects against ischemic limb injury via the cGMP‒PKG signaling pathway, suggesting that it is a promising therapeutic and predictive target for myopathy associated with PAD. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Cyclic GMPCyclic GMP-Dependent Protein KinasesCytokinesMuscle Fibers, SkeletalMuscular DiseasesNicotinamide PhosphoribosyltransferasePeripheral Arterial DiseaseSignal TransductionAnimalsCell LineHumansMaleMiceMice, Inbred C57BLCyclic GMPCyclic GMP-Dependent Protein KinasesCytokinesNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mousecGMP-PKGMitochondriaNAMPTOxidative muscle fiber formationPeripheral artery disease

Identifiers

PMID41310770
PMCPMC12659372

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.