ArticleBMC nutrition2025
Association between prognostic nutritional index and 90-day mortality in septic patients: a retrospective cohort study.
Article in BMC nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Comparative Prognostic Accuracy of Objective Nutritional Indices in Critically Ill Patients with Sepsis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Triglyceride-Glucose Index-Based Nomogram for Predicting Short-Term Mortality in Sepsis Patients.The Kaohsiung journal of medical sciences · 2026Article
- Nutritional-inflammatory-metabolic indices associated with in-hospital mortality in acute kidney injury patients undergoing continuous renal replacement therapy: dose-response analysis and machine learning-based risk stratification.Frontiers in nutrition · 2026Article
- Article
- Lactate-Modified Prognostic Nutritional Index (LPNI) and Its Association with ICU Mortality in Patients with Sepsis: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThis study aimed to investigate the association between the Prognostic Nutritional Index (PNI) and 90-day mortality among patients with sepsis.
methodsWe conducted a retrospective cohort study utilizing data from the MIMIC-IV database for patients diagnosed with sepsis. Covariates were selected using Cox regression models. The association between PNI and 90-day mortality was assessed using multivariable Cox proportional hazards models. We further examined the potential nonlinear relationship using restricted cubic spline(RCS) analysis. Kaplan-Meier survival curves were plotted for these groups, and the differences in 90-day survival rates were compared using the log-rank test.
resultsA total of 5,786 septic patients were included in the final analysis. The overall 90-day mortality rate after ICU admission was 35.0% (n = 2,027). In the fully adjusted Cox model, a higher PNI was associated with a reduced risk of 90-day mortality. Specifically, for each one-unit increase in PNI, the risk of 90-day mortality decreased by 1% (adjusted HR = 0.99, 95% CI: 0.98 ~ 1.00, P = 0.004). The RCS analysis revealed a significant nonlinear relationship between PNI and 90-day mortality (P
conclusionPNI demonstrates a significant nonlinear inverse association with 90-day mortality in patients with sepsis. These findings suggest that PNI could serve as a valuable prognostic tool. Clinicians may use PNI to identify high-risk patients and implement targeted interventions to potentially improve clinical outcomes.
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