Evidence map›Paper›PMID 41310879›Full record

ReviewCell & bioscience2025

Attenuated innate immunity in embryonic stem cells: mechanisms and therapeutic applications.

Sheng Chen, Ruonan Wang, Jingyuan Yang, Xuan Zhou, Shuqun Shen, Hongxin Li, Xinheng Zhang, Weiguo Chen, Qingmei Xie

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sheng Chen *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Ruonan Wang *State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Jingyuan YangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Xuan ZhouState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Shuqun ShenSouthern Medical University, Institute Global Health, Guangzhou, 510642, China.
Hongxin LiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Xinheng ZhangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Weiguo ChenState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. wgchen81@scau.edu.c.
Qingmei XieState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. qmx@scau.edu.cn.

Funding

National Natural Science Foundation of China 32503009the Biological Breeding-National Science and Technology Major Project 2023ZD04053the China Agriculture Research System of MOF and MARA CARS-42-13the Special Project of National Modern Agricultural Industrial Technology System CARS-41
6 · The paper itself

Abstract

Embryonic stem cells (ESCs) possess remarkable pluripotency and self-renewal capacity, making them a cornerstone of regenerative medicine. A defining yet underappreciated feature of ESCs is their attenuated innate immune response, characterized by suppressed expression of pattern recognition receptors, cytokines, and interferons. While this immune hyporesponsiveness helps preserve pluripotency and rapid proliferation during early embryogenesis, it also presents both challenges and opportunities for clinical application. This review summarizes recent findings on the molecular mechanisms underlying the innate immune deficiency of ESCs, including underdeveloped pathogen–sensing machinery and deficiencies in downstream signaling. We further explore the biological significance of this immune state in embryonic development and its implications for stem cell-based therapies. Specifically, we discuss how immune silence can mitigate inflammation during transplantation and be harnessed to improve mRNA-based differentiation and cancer vaccine strategies. Lastly, we highlight the challenges in balancing immune activation with stemness and outline future directions for optimizing ESCs-based therapeutics. A better understanding of ESC immunobiology will enable safer and more effective applications in regenerative medicine, oncology, and immunotherapy.

Indexed as

Embryonic stem cellInnate immunityRegenerative medicineStem cell therapies

Identifiers

PMID41310879
PMCPMC12821913

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.