Evidence map›Paper›PMID 41311083›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[High YEATS2 expression promotes epithelial-mesenchymal transition in gastric cancer cells by activating the Wnt/β-catenin signaling pathway].

Xuening Jiang, Qingqing Huang, Ying Xu, Shunyin Wang, Xiaofeng Zhang, Lian Wang, Yueyue Wang, Lugen Zuo

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xuening JiangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Qingqing HuangAnhui Provincial Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Ying XuAnhui Provincial Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Shunyin WangAnhui Provincial Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Xiaofeng ZhangAnhui Provincial Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Lian WangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Yueyue WangAnhui Provincial Key Laboratory of Basic and Translational Research on Inflammation-related Diseases, Bengbu 233030, China.
Lugen ZuoDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Funding

National Natural Science Foundation of China 82370534
6 · The paper itself

Abstract

objectivesTo investigate YEATS2 expression in gastric cancer (GC), its prognostic value, and its regulatory role in epithelial-mesenchymal transition (EMT) of GC cells.

methodsYEATS2 expression in GC was analyzed using publicly available databases. Paired GC and adjacent tissues were collected from 100 patients undergoing radical surgery for immunohistochemical detection of YEATS2 expression, and its correlations with the patients' clinicopathological parameters and Ki67 expression were analyzed. The prognostic value of YEATS2 was assessed using Kaplan-Meier analysis, Cox regression and ROC curves, and its regulatory mechanisms were analyzed using KEGG enrichment analysis. In cultured GC cell lines (HGC-27 and AGS), the effect of YEATS2 knockdown and overexpression on migration, invasion and EMT of the cells were examined with scratching assay, Transwell assay and Western blotting.

resultsYEATS2 was significantly overexpressed in GC tissues with a positive correlation with Ki67 (

conclusionsHigh YEATS2 expression activates Wnt/β-catenin signaling to promote EMT in GC and is correlated with poor prognosis of GC patients.

Indexed as

Epithelial-Mesenchymal TransitionStomach NeoplasmsWnt Signaling Pathwaybeta CateninCell Line, TumorCell MovementFemaleHumansMalePrognosisbeta Cateninepithelial-mesenchymal transitionGastric cancerprognosisWnt/β-cateninYEATS2

Identifiers

PMID41311083
PMCPMC12676681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.