ArticleThe plant genome2025
The effect of haplotype size on genomic selection accuracy and epistasis: An empirical study in rice.
Article in The plant genome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The effect of haplotype size on genomic selection accuracy and epistasis: An empirical study in rice.The plant genome · 2025Article
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9 authors.
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Abstract
Genomic selection (GS) has revolutionized breeding practices by integrating genotype and phenotype data to predict genomic estimated breeding values, offering the potential to accelerate breeding cycles and intensify and enhance early-stage selections. This approach utilizes the concept of linkage disequilibrium (LD) between genetic markers and quantitative trait loci within populations. LD, the nonrandom association between alleles at different loci, provides valuable insights into historical recombination patterns, although it can change over time under strong selection or genetic drift. This study aimed to investigate the influence of recombination on haplotype sizes and LD, assess the impact of additive (A) versus additive + epistasis (A+I) genetic models on GS predictive ability (PA), and demonstrate how haplotype resolution in the training set (TS) impacts the PA of GS. For this, we used biparental (MP2) and multiparent (MP6-8) populations, where the main difference between them was the recombination rate. As expected, a strong correlation between LD decay and the number of recombination opportunities within populations was observed, with smaller haplotype blocks in populations experiencing more recombination. The use of A+I models increased heritability but did not improve PA. Finally, populations with smaller haplotype sizes in the TS exhibited enhanced PA. This study demonstrates the effect of haplotype size on GS accuracy, and its uniqueness lies in its focus on populations where the primary differentiating factor is haplotype size. It offers an important tool for breeders in designing GS strategies, providing valuable guidance for future breeding efforts.
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