Trial reportJournal of cosmetic dermatology2025
The Sustained Effects of Bioactive Collagen Peptides on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06847035 (Efficacy Study of Oral Collagen Peptide on Skin Conditions), which is not on this map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy Study of Oral Collagen Peptide on Skin Conditions
Who cites it
2 citing papers in PubMed.
- The Sustained Effects of Bioactive Collagen Peptides on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.Journal of cosmetic dermatology · 2025Trial
- Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCollagen is a fundamental component of the skin's extracellular matrix, yet its low oral bioavailability raises questions about its efficacy in improving skin health. Bioactive collagen peptides (BCP), as hydrolyzed forms of collagen, offer enhanced absorption and functionality. However, evidence regarding their sustained effects and the impact of molecular weight distribution is still limited.
aimTo evaluate the long-term effects of BCP supplementation on skin hydration, elasticity, and dermal structure, and to explore the relationship between molecular properties of BCP and skin outcomes.
methodsA randomized, double-blind, placebo-controlled trial was conducted involving 77 healthy female participants aged. Subjects received either 5000 mg/day of BCP or placebo for 12 weeks, followed by a 4-week washout period. Skin parameters-including hydration, transepidermal water loss (TEWL), elasticity, and dermal/epidermal thickness and density-were measured at baseline, Week 8, Week 12, and Week 16 using non-invasive techniques.
resultsBCP significantly improved dermal density, hydration, and TEWL compared to placebo after 12 weeks (p < 0.05). These improvements were maintained during the washout period. Dermal thickness also increased in the BCP group, while no significant changes were noted in the epidermis.
conclusionsTwelve weeks of oral BCP supplementation, followed by a 4-week washout, produced lasting improvements in skin hydration, firmness, and dermal structure. These effects are likely linked to the BCP's high hydroxyproline content and low molecular weight distribution, supporting its use in anti-aging skincare strategies.
trial registrationClinicalTrials.gov identifier: NCT06847035.
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Registered trials
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