Evidence map›Paper›PMID 41311407›Full record

ArticleActa pharmaceutica Sinica. B2025

Brain endothelial HIF-1

Jicong Chen, Ruohui Lin, Cuihua Jiang, Fang Chen, Wei Li, Lei Wang, Ke Pan, Jian Zhang, Zhiqi Yin, Yaping Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Therapeutic potential ofFrontiers in pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jicong ChenSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Ruohui LinSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Cuihua JiangAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.
Fang ChenKey Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 211166, China.
Wei LiAffiliated Jiangning Hospital of Chinese Medicine, China Pharmaceutical University (Nanjing Jiangning Hospital of Chinese Medicine), Nanjing 211100, China.
Lei WangSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Ke PanSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Jian ZhangAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China.
Zhiqi YinSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yaping HuangSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes (T2D) is an independent risk factor for cognitive impairment. The dysregulation of hypoxia inducible factor (HIF) signaling in T2D patients results in impaired adaptive responses to hypoxia, thereby accelerating the progression of complications. However, limited knowledge is available regarding its precise function in diabetes-associated cognitive impairment (DACI). Here, elevated HIF-1

Indexed as

Adult hippocampal neurogenesisAsiatic acidBrain ECsCognitive impairmentGlycolysisHIF-1αLactateType 2 diabetes

Identifiers

PMID41311407
PMCPMC12648004

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.