Evidence map›Paper›PMID 41311459›Full record

ArticleAddiction neuroscience2024

Parvalbumin expression does not account for discrete electrophysiological profiles of glutamatergic ventral pallidal subpopulations.

Robert D Graham, Lisa Z Fang, Jessica R Tooley, Vani Kalyanaraman, Mary Christine Stander, Darshan Sapkota, Michelle R Lynch, Joseph D Dougherty, Bryan A Copits, Meaghan C Creed

Abstract read
In one paragraph

Article in Addiction neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ventral pallidal perineuronal nets regulate opioid relapse.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robert D GrahamDepartment of Anesthesiology, Washington University in St. Louis, United States.
Lisa Z FangDepartment of Anesthesiology, Washington University in St. Louis, United States.
Jessica R TooleyDepartment of Anesthesiology, Washington University in St. Louis, United States.
Vani KalyanaramanDepartment of Anesthesiology, Washington University in St. Louis, United States.
Mary Christine StanderDepartment of Anesthesiology, Washington University in St. Louis, United States.
Darshan SapkotaDepartment of Biological Sciences, University of Texas at Dallas, United States.
Michelle R LynchDepartment of Anesthesiology, Washington University in St. Louis, United States.
Joseph D DoughertyGraduate program in neuroscience, Division of Biological and Biomedical Sciences, United States.
Bryan A CopitsDepartment of Anesthesiology, Washington University in St. Louis, United States.
Meaghan C CreedDepartment of Anesthesiology, Washington University in St. Louis, United States.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
BIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8M
Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intakeR01DA056829 · NIDA · WASHINGTON UNIVERSITY · PI Meaghan C Creed, Vijay K Samineni · 2023 to 2026
$3.2M
Dissecting ventral pallidal plasticity in punishment-resistant opioid self-administrationR01DA058755 · NIDA · WASHINGTON UNIVERSITY · PI Meaghan C Creed · 2023 to 2026
$2.5M
Dissecting the role of ventral pallidal projections to nucleus accumbens in reward processingR01DA049924 · NIDA · WASHINGTON UNIVERSITY · PI CREED, MEAGHAN C · 2020 to 2024
$2.0M
The WUSTL PREP post-bacc program to enhance doctoral readiness in neuroscienceR25NS130965 · NINDS · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner, Jose A Moron-Concepcion · 2023 to 2026
$1.4M
NCI NIH HHS P30 CA091842NIDA NIH HHS R01 DA049924NIDA NIH HHS R01 DA056829NIDA NIH HHS R01 DA058755NIDA NIH HHS T32 DA007261NIDDK NIH HHS P30 DK020579NINDS NIH HHS R25 NS130965
6 · The paper itself

Abstract

The ventral pallidum (VP) has emerged as a critical node in the mesolimbic reward system. Modulating the VP can impact the subjective valuation of rewards, reward motivation, and reward seeking under conflict, making it an attractive target for clinical neuromodulation therapies that manage substance use disorders. To understand how to rationally modulate the VP, we need a better understanding of the electrophysiological properties of VP neurons and the molecular and biophysical determinants of these properties. Here, we used patch-clamp electrophysiology to characterize the intrinsic properties of glutamatergic VP (VP

Indexed as

ElectrophysiologyIon channelsMarkov chain Monte-CarloNeuron modelingTranslating ribosome affinity purification

Identifiers

PMID41311459
PMCPMC12656895

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.