Evidence map›Paper›PMID 41311461›Full record

ArticleFood hydrocolloids2026

Impact of Whey Protein on the Physico-Mechanical Properties of Alginate Dialdehyde Scaffolds and Cell Adhesion for Cultivated Meat Applications.

Chris Foley, Rachael A Floreani

Abstract read
In one paragraph

Article in Food hydrocolloids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chris FoleyDepartment of Mechanical Engineering, University of Vermont, Burlington, VT USA.
Rachael A FloreaniDepartment of Mechanical Engineering, University of Vermont, Burlington, VT USA.

Funding

Nikon A1R-ER Confocal Microscope for the Microscopy Imaging CenterS10OD025030 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TAATJES, DOUGLAS J. · 2018 to 2018
$557k
NIH HHS S10 OD025030
6 · The paper itself

Abstract

This article highlights the advantages of incorporating whey protein conjugation into polysaccharide hydrogels to enhance cell adhesion for cultivated meat applications. Here we show, for the first time, that controlling Schiff-base bond formation between whey protein isolate (WPI) and alginate dialdehyde (AlgDA) created hydrogel materials with significant differences in physico-mechanical properties including equilibrium swell ratio, hydrolytic weight loss, axial stiffness, and strength. The newly formed bonds retain WPI within the hydrogel network and limit leaching of non-bound protein. In addition, AlgDA went through a secondary crosslinking step via the introduction of divalent cations. Immortalized bovine satellite cells (iBSCs) cultured on WPI-modified materials indicated higher metabolic activity and adhesion. The results show significant advantages of WPI to encourage cell adhesion and warrant further investigation for cultivated meat research and production.

Indexed as

alginatecultivated meatiBSCsmechanical propertiesscaffoldswhey protein

Identifiers

PMID41311461
PMCPMC12652571

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.